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Table 3 Univariate analysis for factors associated with genotoxicity assays performed with urine extracts on HepG2 cells: statistical significance of associations (N = 64).

From: Integrated exposure assessment of sewage workers to genotoxicants: an urinary biomarker approach and oxidative stress evaluation

Independent variables

P-value

 

Tail DNA percent

MNi/1000 BNed

Socio-demographic characteristics

  

   Marital status (married/not married)

0.12

0.94

   Smoking (ex-smokers/never smokers)

0.16

0.18

Educational level; years (> 12/≤ 12)

0.04

0.23

Age; years (≤ 39/> 39)

0.01

0.02

   Alcohol consumption (regularly/occasionally)

0.09

0.05

   Vegetable intake (usually/sometimes)

0.05

0.02

VOCs

  

   Benzene

0.01

0.001

   Toluene

0.14

0.004

   Ethylbenzene

0.01

0.001

   M+P-Xylene

0.002

< 0.001

   O-Xylene

0.003

< 0.001

   1, 2,4 Trimethylebenzene

0.02

< 0.001

   Undecane

0.05

< 0.001

   Trichloroethylene

0.07

0.05

   Tetrachloroethylene

0.01

0.19

   Styrene

0.09

0.002

   Decane

0.001

< 0.001

   1,4 Dichlorobenzene

0.06

0.02

PAHs

  

   Benzo(a)pyrene

0.40

0.35

   Anthracene

0.02

0.17

   Benz(a)anthracene

0.20

0.20

   Benzo(b)fluoranthene

0.16

0.22

   Benzo(g,h,i)perylene

0.09

0.22

   Benzo(k)fluornathene

0.21

0.24

   Chrysene

0.01

0.03

   Dibenz(a,h)anthracene

0.02

0.51

   Fluoranthene

0.04

0.06

   Indeno(1,2,3-cd)pyrene

0.08

0.20

   Phenanthrene

0.01

0.03

   Pyrene

0.03

0.11

   Benzo(j)fluoranthene

0.06

0.26

   Total [B(a)P]eq

0.15

0.34

  1. Total [B(a)p]eq, total Benzo(a)pyrene equivalent concentration
  2. MNi, micronuclei
  3. BNed; binucleated cells