Integrated exposure assessment of sewage workers to genotoxicants: an urinary biomarker approach and oxidative stress evaluation

Al Zabadi, Hamzeh; Ferrari, Luc; Sari-Minodier, Irène; Kerautret, Marie-Aude; Tiberguent, Aziz; Paris, Christophe; Zmirou-Navier, Denis

doi:10.1186/1476-069X-10-23

Environmental Health

Table 4 Association between exposures to workplace toxicants and genotoxicity assays performed on HepG2 cells: multiple linear regression models (N = 64)*.

From: Integrated exposure assessment of sewage workers to genotoxicants: an urinary biomarker approach and oxidative stress evaluation

Independent variable	Tail DNA percent			MNi/1000 BNed
	Reg. coeff #	P-value	95% CI for B	Reg. coeff #	P-value	95% CI for B
VOCs
Benzene
≤ 39 yrs	0.03	0.61	-0.08 to 0.14	0.03	0.78	-0.17 to 0.23
> 39 yrs	0.08	0.03	0.01 to 0.16	0.41	0.00	0.23 to 0.56
Ethylbenzene
≤ 39 yrs	0.02	0.24	-0.01 to 0.05	-0.01	0.80	-0.06 to 0.05
> 39 yrs	0.02	0.05	0.00 to 0.03	0.10	0.00	0.07 to 0.13
M+P-Xylene
≤ 39 yrs	0.01	0.09	-0.002 to 0.02	0.002	0.9	-0.02 to 0.03
> 39 yrs	0.01	0.03	0.001 to 0.02	0.05	0.00	0.03 to 0.06
O-Xylene
≤ 39 yrs	0.03	0.12	-0.01 to 0.06	0.01	0.66	-0.05 to 0.07
> 39 yrs	0.02	0.04	0.001 to 0.03	0.11	0.00	0.07 to 0.14
Decane
≤ 39 yrs	0.01	0.07	-0.001 to 0.02	0.003	0.76	-0.02 to 0.02
> 39 yrs	0.01	0.03	0.001 to 0.01	0.04	0.00	0.03 to 0.05
Tetrachloroethylene				NT	NT	NT
≤ 39 yrs	0.02	0.31	-0.02 to 0.05
> 39 yrs	0.01	0.002	0.004 to 0.02
Trichloroethylene
≤ 39 yrs	0.003	0.84	-0.03 to 0.04	-0.03	0.27	-0.10 to 0.03
> 39 yrs	0.02	0.02	0.003 to 0.03	0.06	0.002	0.03 to 0.10
Toluene	NT	NT	NT
≤ 39 yrs				-0.004	0.57	-0.02 to 0.01
> 39 yrs				0.02	0.00	0.01 to 0.03
1,4 Dichlorobenzene^§	0.01	0.39	-0.01 to 0.03
≤ 39 yrs				-0.03	0.38	-0.10 to 0.04
> 39 yrs				0.11	0.00	0.06 to 0.16
1, 2,4Trimethylebenzene^§	0.01	0.12	-0.002 to 0.02
≤ 39 yrs				0.01	0.81	-0.03 to 0.04
> 39 yrs				0.07	0.00	0.05 to 0.09
Undecane^§	0.003	0.23	-0.002 to 0.01
≤ 39 yrs				0.01	0.14	-0.004 to 0.03
> 39 yrs				0.03	0.00	0.02 to 0.03
Styrene^§	0.03	0.36	-0.03 to 0.09
≤ 39 yrs				-0.07	0.52	-0.29 to 0.15
> 39 yrs				0.34	0.00	0.23 to 0.44
PAHs
Chrysene^£				0.10	0.50	-0.19 to 0.38
≤ 39 yrs	0.07	0.57	-0.18 to 0.32
> 39 yrs	0.20	0.04	0.01 to 0.39
Fluranthene^£				0.02	0.68	-0.07 to 0.10
≤ 39 yrs	-0.002	0.96	-0.07 to 0.07
> 39 yrs	0.09	0.02	0.02 to 0.16
Phenanthrene^£				0.01	0.51	-0.02 to 0.05
≤ 39 yrs	0.01	0.67	-0.02 to 0.04
> 39 yrs	0.04	0.01	0.01 to 0.07
Pyrene				NT	NT	NT
≤ 39 yrs	0.004	0.92	-0.09 to 0.10
> 39 yrs	0.08	0.03	0.01 to 0.15
Anthracene				NT	NT	NT
≤ 39 yrs	0.02	0.88	-0.24 to 0.27
> 39 yrs	0.25	0.01	0.06 to 0.44
Benzo(g,h,i)perylene				NT	NT	NT
≤ 39 yrs	-0.01	0.96	-0.33 to 0.31
> 39 yrs	0.20	0.04	0.01 to 0.39
Indeno(1,2,3-cd)pyrene				NT	NT	NT
≤ 39 yrs	-0.01	0.98	-0.49 to 0.48
> 39 yrs	0.34	0.03	0.03 to 0.65
Benzo(j)fluoranthene				NT	NT	NT
≤ 39 yrs	-0.01	0.98	-0.37 to 0.36
> 39 yrs	0.26	0.04	0.02 to 0.51
Dibenz(a,h)anthracene^§	0.85	0.02	0.13 to 10.57	NT	NT	NT

* Variables in the final models. (i) MNi/1000 BNed models: toxicants (one each time), age (≤ 39/>39 years), toxicant-age interaction, alcohol consumption (regularly/occasionally), vegetable intake (usually/sometimes).
(ii) tail DNA percent models: same as MNi/1000 BNed plus level of education (>12/≤12 years).
^§ or ^£ Not significant interaction between toxicant and age for comet^§ or micronuclei^£ assays. Toxicant effect adjusted for the other models variables.
NT: Not Tested because P > 0.1 in univariate association between toxicant and biomarker (table 2).
Notes: Variables entered in the models are those with P < 0.1 in univariate analysis. Enter method was used.
Reg. coeff #, regression coefficient number
CI, confidence interval
yrs, years
MNi, micronuclei
BNed; binucleated cells.

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ISSN: 1476-069X

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