Prostate cancer and toxicity from critical use exemptions of methyl bromide: Environmental protection helps protect against human health risks

Table 2 Overview of epidemiological studies on methyl bromide effects (1990-2011)

Reference	Study design	Magnitude of study	Specified measure 1			Exposure to methyl bromide	cases			p value high vs. low
study	year			sample size	location		cancer (prostate)	Odds Ratio adjusted	95% CI
[28]	2003	cohort study	occupational agriculture, farmers	55, 332	USA, IA, NC	exposed/controls *84/482	84	1.10	0.77, 1.36	0.004
						low exposure	6	2.73	1.18, 6.33
						high exposure	5	3.47	1.37, 8.76
[29]	2010	data analysis	occupational agriculture, farmers	55, 332	USA, IA, NC		5	3.47	1.37, 8.76	0.004
[30]	2003	case-control study	occupational agriculture, Hispanic farm workers	1, 332	USA, CA	exposed/controls 121/1110	64	1.17	0.77, 1.75	0.25
						low exposure	37	1.20	0.66, 2.18
						high exposure	32	1.59	0.77, 3.30
[31]	2011	case-control study	population, near intensive agricult. areas		USA, CA	exposed/controls 173/162	87	1.62	1.02, 2.59	0.1
						low exposure	45	1.81	1.03, 3.18
						high exposure	42	1.45	0.82, 2.57
[29]	2010	data analysis	occupational agriculture, farmers	55, 332	USA, IA, NC		5	3.47	1.37, 8.76	0.004
							toxic effects
[32]	2006	cohort study	population, farmers' wives		USA, CA	exposed/controls *145/797		1.82	1.02-3.24

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