Substances dataset | Dose metric | Species | Results | Reference |
---|---|---|---|---|
190 chemicals | TD50 | Mouse and rat | Median TD50Mouse/TD50Rat ratio = 2.4 | [70] |
20% of ratios exceeded 10 | ||||
69 pesticides | NOAEL | Mouse, rat and dog | NOAELRat /NOAELDog : 1.58 (0.99-2.24) | [71] |
NOAELMouse /NOAELRat : 3.87 (2.24-6.32) | ||||
NOAELMouse /NOAELDog : 7.07 (3.53-13.42) | ||||
Binary interspecies comparisons from dozens to over 500 agents | Mostly LC50 | Aquatic species | Orders-within-Classes Extrapolation | [72] |
Weighted mean of uncertainty factor (UF) prediction interval (PI): 26 (95% PI), 35 (99% PI) | ||||
Upper 95% UFs: 65 (95% PI), 88 (99% PI) | ||||
184 substances | NOAEL | Mouse, rat, dog | NOAELRat /NOAELDog : 1.3 (P95 =18.8) | [49] |
NOAELMouse /NOAELRat : 4.2 (P95 = 73.9) | ||||
NOAELMouse / NOAELDog : 6.4 (P95 = 124.6) | ||||
198 substances | NOAEL | Mouse, rat, dog | NOAELRat /NOAELDog : 2.3 (P95 =27) | [73] |
NOAELMouse /NOAELRat : 3.2 (P95 = 37) | ||||
NOAELMouse /NOAELDog : 5.9 (P95 = 50) | ||||
217 substances | LD50 | Mouse, hamster, guinea pig, rat, cat, rabbit, monkey dog | LD50Mouse/LD50Rat= 0.86 (P95 = 2.52) | |
LD50Hamster/LD50Rat= 1.2 (P95 = 1.33) | ||||
LD50Guinea pig/LD50Rat= 0.71 | ||||
(P95 = 2.96) | [68] | |||
LD50Cat/LD50Rat= 0.31 (P95 = 1.47) | ||||
LD50Rabbit/LD50Rat= 0.76 (P95 = 2.46) | ||||
LD50Monkey/LD50Rat= 0.63 (P95 = 0.88) | ||||
LD50Dog/LD50Rat= 0.82 (P95 = 4.87) | ||||
216 pesticides | NOAEL | Mouse, rat, dog | NOAELMouse/NOAELRat = 2.22 (P95 = 24.2) NOAELRat/NOAELDog = 1.70 (P95 = 16.6) | [68] |
NOAELMouse/NOAELDog = 6.00 (P95 = 44.8) | ||||
58 compounds | NOAEL and Critical Effect Dose (CED) | Mouse, rat | NOAELMouse/NOAELRat : P95 = 15.5; GSD = 3.4 | [74] |
CEDMouse /CEDRat : P95 = 5.6 | ||||
Default value of 10 corresponds to 49th percentile and 71st percentile of mouse to human and rat to human distributions respectively |