Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants – a Dutch prospective cohort study

de Cock, Marijke; de Boer, Michiel R; Lamoree, Marja; Legler, Juliette; van de Bor, Margot

doi:10.1186/1476-069X-13-106

Environmental Health

Table 4 Regression coefficients for various exposures in girls (in quartiles) and T4 (nmol/L)

From: Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants – a Dutch prospective cohort study

	n	Q1	Q2		Q3		Q4
Compound			β (95% CI)	p-value	β (95% CI)	p-value	β (95% CI)	p-value
DDE (Total, ng/L)		<41.80	41.80 – 74.50		74.51 – 107.50		>107.50
Crude	70	Ref	0.7 (-16.17, 17.48)	0.938	3.9 (-14.66, 22.47)	0.675	20.2^* (1.59, 38.71)	0.034
Model A¹	65	Ref	3.0 (-14.66, 20.69)	0.734	2.3 (-17.14, 21.80)	0.811	24.4^* (2.30, 46.47)	0.031
Model B²	61	Ref	8.7 (-10.00, 27.45)	0.350	8.6 (-13.00, 30.18)	0.424	24.8^* (0.79, 48.75)	0.043
MECPP (ng/mL)		<0.22	0.22 – 0.27		0.28 – 0.38		>0.38
Crude	63	Ref	-1.6 (-22.55, 19.30)	0.877	-12.0 (-36.62, 12.62)	0.333	11.3 (-13.37, 35.87)	0.363
Model A¹	57	Ref	3.4 (-18.62, 25.37)	0.759	-10.3 (-38.03, 17.52)	0.461	16.3 (-11.69, 44.36)	0.247
Model B²	52	Ref	6.2 (-24.71, 37.04)	0.685	-14.5 (-45.49, 16.44)	0.344	14.0 (-14.01, 42.07)	0.314
MEHHP (ng/mL)		<0.18	0.18 – 0.27		0.28 – 0.39		>0.39
Crude	63	Ref	-9.3 (-34.00, 15.47)	0.456	-8.0 (-28.68, 12.68)	0.441	-3.2 (-30.24, 23.91)	0.815
Model A¹	57	Ref	-7.8 (-35.52, 20.00)	0.575	-8.1 (-29.95, 13.66)	0.456	-1.5 (-29.50, 26.41)	0.912
Model B²	52	Ref	-5.7 (-49.41, 38.11)	0.793	-11.2 (-35.27, 12.94)	0.350	-0.4 (-30.20, 29.43)	0.979
MEOHP (ng/mL)		<0.17	0.17 – 0.23		0.24 – 0.41		>0.41
Crude	63	Ref	-10.5 (-32.11, 11.08)	0.333	6.6 (-18.83, 32.07)	0.604	-10.2 (-30.73, 10.30)	0.322
Model A¹	57	Ref	-12.8 (-36.53, 10.91)	0.283	2.5 (-30.01, 34.94)	0.879	-9.7 (-32.80, 13.37)	0.401
Model B²	52	Ref	-19.6 (-47.55, 8.30)	0.161	1.6 (-35.19, 38.30)	0.932	-12.5 (-40.01, 19.92)	0.357
PFOS (ng/L)		<1026	1026 – 1600		1601 – 2175		>2175
Crude	62	Ref	-3.3 (-24.28, 17.65)	0.752	-2.7 (-27.42, 22.00)	0.826	9.5 (-10.46, 29.37)	0.345
Model A¹	57	Ref	2.3 (-21.13, 25.69)	0.845	-1.4 (-27.00, 24.17)	0.912	10.2 (-10.90, 31.24)	0.336
Model B²	52	Ref	-1.3 (-30.45, 27.94)	0.930	4.5 (-25.95, 34.92)	0.766	15.9 (-10.67, 42.40)	0.231
PFOA (ng/L)		<591	591 – 865		866 – 1200		>1200
Crude	62	Ref	-3.6 (-23.09, 15.90)	0.713	2.6 (-19.40, 24.54)	0.815	22.8^* (0.86, 44.79)	0.042
Model A¹	57	Ref	-1.5 (-22.39, 19.40)	0.886	11.3 (-14.23, 36.79)	0.378	27.8^* (5.03, 50.64)	0.018
Model B²	52	Ref	-5.9 (-26.75, 14.94)	0.566	11.8 (-19.08, 42.72)	0.439	38.6^* (13.34, 63.83)	0.004

¹Adjusted for thyroid gland problems, use of thyroid medication, and birth weight. Caesarean section was constant and not included in the model.
²Model A + additionally adjusted for gestational weight gain, gestational age, parity, smoking, alcohol, maternal BMI, and maternal age at birth.
^*p < 0.05

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ISSN: 1476-069X

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