Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study

Table 5 Interaction between the number of variant GST ^a genotypes and indoor stove/fireplace use and breast cancer ^b

Number of GST^avariants	Indoor stove/ fireplace use	Cases (n)	Controls (n)	Age-adjusted OR (95% CI)	Multivariable-adjusted OR (95% CI)^c
	Ever any
<2 variants	No stove/fireplace	452	483	1.00 (reference)	1.00 (reference)
	Ever any stove/fireplace	424	419	1.06 (0.96, 1.16)	1.04 (0.93, 1.16)
≥2 variants	No stove/fireplace	305	298	1.12 (0.93, 1.35)	1.08 (0.87, 1.35)
	Ever any stove/fireplace	323	349	1.19 (0.89, 1.58)	1.13 (0.81, 1.57)
	Wood burning ^d
<2 variants	No stove/fireplace	452	483	1.00 (reference)	1.00 (reference)
	Ever wood burning	378	377	1.05 (0.96, 1.16)	1.02 (0.91, 1.15)
≥2 variants	No stove/fireplace	305	298	1.11 (0.92, 1.35)	1.05 (0.83, 1.32)
	Ever wood burning	296	322	1.17 (0.88, 1.57)	1.07 (0.76, 1.51)
	Synthetic log burning
<2 variants	No stove/fireplace	452	483	1.00 (reference)	1.00 (reference)
	Ever synthetic log	146	112	1.22 (1.07, 1.38)	1.19 (1.03, 1.39)
≥2 variants	No stove/fireplace	305	298	1.48 (1.15, 1.91)	1.43 (1.06, 1.93)
	Ever synthetic log	100	90	1.81 (1.24, 2.63)	1.71 (1.09, 2.68)

^aNumber of GST variants = total number of variant genotypes from any of the GST SNPs considered in this study, including: GSTA1, GSTT1, GSTM1, GSTP1 (see text). Common alleles: GSTT1 present, GSTM1 present, GSTA1*A, GSTP1 (AA). Variant alleles: GSTT1 null, GSTM1 null, GSTA1*B, GSTP1 (AG or GG).
^bAmong Long Island, NY women, LIBCSP, 1996-1997.
^cMultivariate OR adjusted for age, age at menarche, history of breastfeeding, hormone therapy use,
family history of breast cancer, parity, age at first birth, BMI at reference, education, smoking history,
alcohol intake, physical activity, race, religion, marital status.
^dWood burning excludes synthetic logs.

ISSN: 1476-069X