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Table 4 Incidence of lung tumors and mesotheliomas in rats following exposure to asbestos samples (from [[65],[66]])

From: Quantification of short and long asbestos fibers to assess asbestos exposure: a review of fiber size toxicity

Inhalation 10 mg/m3*

 

Amosite

 

LAF

SAF

11% >10 μm

0.1% > 10 μm

Number of rats

40

42

Lung tumor

11 (27.5%)

0 (0%)

Mesothelioma

3 (7.5%)

1 (2.4%)

 

Chrysotile

 

LAF

SAF

2% >10 μm

0.7% > 10 μm

0.1% >30 μm

0.03% >30 μm

Number of rats

40

40

Lung tumor

20 (50%)

7 (17.5%)

Mesothelioma

3 (7.5%)

1 (2.4%)

Mesotheliomas after intraperitoneal injection**

 

Amosite

 

LAF

SAF

Number of rats

Not provided

Not provided

10 mg

21 (88%)

0 (0%)

25 mg

20 (90%)

1 (4%)

 

Chrysotile

Number of rats

24

24

2.5 mg

22 (91.6%)

8 (33.3%)

25 mg

23 (95.8%)

22 (91.6%)

  1. *Inhalation: 2 lung tumors and no mesothelioma in control rats.
  2. **Intraperitoneal injection: no mesothelioma in control rats.