Skip to main content


Figure 3 | Environmental Health

Figure 3

From: Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study

Figure 3

Biocomputational profiling of disease-linked MAPK (epi)gene hits. A heatmap (left) of methylation coefficients for the three pollution paradigms—black carbon (BC), sulfates (S), and BC with sulfate (BCS)—and a corresponding disease ontology table (right) are shown. Only genes with an annotation within the disease ontology [51] are shown: i.e., 11 out of 27 MAPK genes (~41%). Heatmap colors represent the methylation coefficients, with negative values in blue, zero in white, and positive values in red. Rows within both the heatmap and the concept-map represent individual genes as noted. Columns within the disease ontology concept-map represent individual diseases within the disease ontology. Disease category hierarchies were collapsed, so diseases may represent subcategories of other diseases represented (e.g., “Breast cancer” and “Ovarian cancer” are both sub-categories of “Cancer”). Dots within the disease ontology table denote an association of a gene with a given pathology. Alternative shading is used to help demarcate columns.

Back to article page