Figure 2From: Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessmentMechanism of the NMDR relationship phenomenon induced by the “plurality of molecular targets”. At low concentrations, EDC binds to the A receptors and induces the observed effect. At high concentrations, the A receptors are still activated and EDC binds to the B receptors, which induces the opposite effect, resulting in an NMDR. Notes: A = Receptor A; B = Receptor B; xe = xenobiotic (e.g., EDC); affinity for A > B.Back to article page