Table 1 Genes altered following oxythioquinox exposure. Table represents data mined from HuGeneFL microarrays (Affymetrix). All genes selected have a signal log ratio of ± 0.6 unless otherwise noted. Representative genes for each group were selected based on their function and are shown here.
GenBank ID | Name | Peak Expression Level (SLR) | Functional Class |
|---|---|---|---|
Genes increased in three or more strains (n = 13): | |||
   U22028 | CYP2A13 | 1.5 | xenobiotic metabolism |
   U20734 | junB | 3.42 | transcription |
   V01512 | cfos | 2.04 | transcription |
   S85655 | prohibitin | 0.75 | cell proliferation |
   S82240 | RhoE GTPase | 2.81 | signal transduction |
   M69043 | MAD-3 mRNA encoding IkB-like activity | 0.83 | apoptosis |
   M63573 | cyclophilin | 1.68 | immune response |
   U05861 | Dihydrodiol dehydrogenase | 2.52 | xenobiotic metabolism |
Genes decreased in three or more strains (n = 23): | |||
   L05624 | MAP Kinase Kinase | -0.67 | signal transduction |
   U18018 | E1A enhancer | -1.34 | transcription |
   X56681 | junD | -1.03 | transcription |
   X68836 | S-adenosylmethionine synthetase | -2.57 | cell metabolism |
   J04973 | Cytochrome bc-1 | -3.12 | cell metabolism |
Genes altered in at least two of four cell strains (n = 189): | |||
   X03484 | raf oncogene | 1.46 | carcinogenesis |
   M60974 | growth arrest and DNA-damage-inducible protein (gadd45) | 1.51 | DNA damage |
   M57731 | Human gro-beta | 1.85 | immune response |
   X66899 | EWS | 1.2 | carcinogenesis |
   Z29087* | Cyclin D1 Promoter | 1.03 | cell cycle control |
   L10910 | Splicing Factor CC1.3 | 0.62 | RNA processing |
   M83667 | NF-IL6 Permeability Factor | 1.55 | transcription |
   M27281 | Vascular Permeability Factor | -1.09 | cell proliferation |
   L28010 | HnRNP F protein | -0.55 | RNA processing |
   U72649 | BTF2 | -1.86 | carcinogenesis |
   M19267 | tropomyosin | -1.16 | cardiac |
   M38258 | retinoic acid receptor gamma 1 | -0.94 | cell metabolism |
   U42031 | Immunophilin | -1.41 | immune response |
   U67122 | ubiquitin-related SUMO-1 | -1.03 | protein metabolism |
   X70340 | Transforming growth factor alpha | -0.57 | cell proliferation |
   M34458 | Lamin B | -1.33 | cell proliferation |