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Table 5 Linear regression analyses of xenohormone transactivities before and upon adjustment for lifestyle characteristics

From: Xenohormone transactivities are inversely associated to serum POPs in Inuit

Xenoestrogenic transactivities (XERcomp)

Male serum

Nuuk

Sisimiut

Qaanaaq

All

  

n

β

p

n

β

p

n

β

p

n

β

p

ΣPCB

Non-adjusted

32

-.26

.15

51

-.08

.56

36

-.24

.17

119

.22

.02

 

+age

-

-

-

-

-

-

-

-

-

119

-.00

.99

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

105

.27

.06

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

105

.10

.47

Σpesticide

Non-adjusted

32

-.32

.07

51

-.13

.37

36

-.21

.21

119

.17

.07

 

+age

-

-

-

-

-

-

-

-

-

119

-.07

.50

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

105

.13

.39

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

105

-.03

.86

ΣPOP

Non-adjusted

32

-.30

.09

51

-.11

.45

36

-.24

.17

119

.20

.03

 

+age

-

-

-

-

-

-

-

-

-

119

-.04

.71

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

105

.21

.16

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

105

.04

.80

Female serum

Nuuk

Sisimiut

Qaanaaq

All

  

n

β

p

n

β

p

n

β

p

n

β

p

ΣPCB

Non-adjusted

44

.11

.49

42

-.06

.70

30

-.01

.96

116

-.14

.14

 

+age

-

-

-

-

-

-

-

-

-

116

-.18

.07

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

112

.05

.62

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

112

.01

.92

Σpesticide

Non-adjusted

44

.02

.90

42

-.09

.58

30

-.14

.48

116

-.20

.03

 

+age

-

-

-

-

-

-

-

-

-

116

-.24

.01

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

112

-.02

.84

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

112

-.06

.58

ΣPOP

Non-adjusted

44

.05

.74

42

-.08

.62

30

-.10

.61

116

-.18

.06

 

+age

-

-

-

-

-

-

-

-

-

116

-.22

.03

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

112

.01

.94

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

112

-.04

.76

Xenoandrogenic transactivities (XARcomp)

Male serum

Nuuk

Sisimiut

Qaanaaq

All

  

n

β

p

n

β

p

n

β

p

n

β

p

ΣPCB

Non-adjusted

34

-.07

.70

33

.003

.99

37

.17

.32

104

-.05

.62*

 

+age

-

-

-

-

-

-

-

-

-

104

-.39

.001

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

98

-.22

.14

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

98

-.42

<.01

Σpesticide

Non-adjusted

34

-.01

.96

33

.06

.76

37

.10

.54

104

-.04

68*

 

+age

-

-

-

-

-

-

-

-

-

104

-.36

<.01

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

98

-.20

.19

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

98

-.36

.01

ΣPOP

Non-adjusted

34

-.04

.83

33

.04

.85

37

.13

.44

104

-.04

.67*

 

+age

-

-

-

-

-

-

-

-

-

104

-.38

.001

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

98

-.21

.17

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

98

-.40

<.01

Female serum

Nuuk

Sisimiut

Qaanaaq

All

  

n

β

p

n

β

p

n

β

p

n

β

p

ΣPCB

Non-adjusted

40

.09

.60

28

-.21

.29

31

.13

.47

99

-.06

.56

 

+age

-

-

-

-

-

-

-

-

-

99

-.07

.50

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

97

-.04

.75

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

97

-.06

.68

Σpesticide

Non-adjusted

40

.15

.35

28

-.26

.19

31

.08

.67

99

-.06

55

 

+age

-

-

-

-

-

-

-

-

-

99

-.07

.50

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

97

-.05

.74

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

97

-.06

.67

ΣPOP

Non-adjusted

40

.13

.43

28

-.23

.24

31

.10

.59

99

-.06

57

 

+age

-

-

-

-

-

-

-

-

-

99

-.07

.52

 

+n-3/n-6

-

-

-

-

-

-

-

-

-

97

-.04

.77

 

+age+n-3/n-6

-

-

-

-

-

-

-

-

-

97

-.06

.70

  1. Adjustment for BMI, smoker years and bird intake did not further change the data.
  2. The overall association between the POP markers and xenohormone transactivity across the study groups were evaluated using multiple linear regressions analysis. Homogeneity across the districts was observed (see Additional file 1) and to improve the statistical power and the overall trend of the study groups the combined male and female data across the districts was evaluated.
  3. *: The combined data of Sisimiut and Qaanaaq men was significantly negatively correlated to non-adjusted as well as age adjusted POPs.
  4. -: The data of the single districts were not adjusted for lifestyle characteristics because of the few cases in each district (n = 31 – 40).
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Environmental Health

ISSN: 1476-069X