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Table 1 Increase in dopamine level by TCDD exposure to N2a-Rβ cells

From: Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study

L-dopa and catecholamines

Amount

Fold increase

 

DMSO

TCDD

 

L-dopa (ng/2 × 107cells)

118.8 ± 18.9

208.8 ± 18.0

1.75**

Dopamine (ng/2 × 107cells)

17.7 ± 2.7

28.1 ± 2.9

1.59**

Noradrenaline (pg/2 × 107cells)

66.8 ± 11.1

71.5 ± 8.6

1.07

Adrenaline (pg/2 × 107cells)

N.D.

N.D.

N.D.

  1. L-dopa and catecholamines in N2a-Rβ cells were measured by a fluorescent HPLC method. Amounts of L-dopa and dopamine were significantly higher in TCDD-exposed N2a-Rβ cells as compared to unexposed N2a-Rβ cells. Fold increase represents the ratios of the amounts in TCDD-exposed cells to those in unexposed cells. No change was observed in the amount of noradrenaline with or without TCDD exposure to N2a-Rβ cells.
  2. Values are mean ± SD of four replicate determinations. ND, not detected. **P < 0.01.