Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

Schreinemachers, Dina M

doi:10.1186/1476-069X-9-11

Environmental Health

Table 3 Linear regression analysis of log(triglycerides) on 2,4-D and covariates for ages 20-59, NHANES III, 1988-1994.

From: Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

Independent variables	All available subjects (n = 708)	Susceptible subpopulations
		HbA1c > 5.1%	T4 ≤ 8.5 μg/dl
		(n = 345)	(n = 344)
	Estimate (95% CI)	Estimate (95% CI)	Estimate (95% CI)
Intercept	6.993	6.575	6.976
	(6.296, 7.690)^a	(5.525, 7.624)^a	(5.929, 8.023)^a
2,4-D, binary	1.804	3.119	1.791
	(0.410, 3.199)^c	(0.958, 5.279)^b	(-0.180, 3.761)
Log(HDL) for 2,4-D < LOD	-0.644	-0.570	-0.660
	(-0.791, -0.497)^a	(-0.798, -0.342)^a	(-0.879, -0.440)^a
Log(HDL) for 2,4-D ≥ LOD	-1.119	-1.378	-1.150
	(-1.467, -0.771)^a	(-1.908, -0.847)^a	(-1.635, -0.664)^a
Log (urinary creatinine)	-0.026	-0.001	0.006
	(-0.080, 0.028)	(-0.082, 0.081)	(-0.076, 0.088)
Gender	0.034	0.004	0.006
	(-0.043, 0.112)	(-0.111, 0.120)	(-0.114, 0.126)
Age (years)	0.007	0.008	0.008
	(0.004, 0.011)^a	(0.003, 0.013)^b	(0.003, 0.013)^b
Non-Hispanic Black	-0.130	-0.119	-0.160
	(-0.219, -0.041)^b	(-0.255, 0.016)	(-0.292, -0.027)^c
Mexican American	0.079	0.130	0.099
	(-0.014, 0.172)	(-0.016, 0.276)	(-0.053, 0.251)
Other ethnicity	0.185	0.077	0.359
	(-0.033, 0.402)	(-0.226, 0.380)	(0.040, 0.677)^c
Past smoker	0.019	-0.012	0.040
	(-0.079, 0.117)	(-0.154, 0.130)	(-0.104, 0.183)
Active smoker	0.103	0.028	0.080
	(0.022, 0.183)^b	(-0.093, 0.148)	(-0.043, 0.202)
BMI 25-29 kg/m²	0.242	0.245	0.296
	(0.159, 0.325)^a	(0.117, 0.373)^a	(0.173, 0.419)^a
BMI ≥ 30 kg/m²	0.346	0.277	0.315
	(0.248, 0.444)^a	(0.140, 0.415)^a	(0.162, 0.468)^a
Alcohol consumption	0.056	0.094	0.050
	(-0.071, 0.184)	(-0.088, 0.275)	(-0.117, 0.217)
Income ≥ 20K (%)	-0.015	0.045	0.003
	(-0.090, 0.060)	(-0.064, 0.154)	(-0.113, 0.119)
Hours of fasting	-0.014	-0.013	-0.020
	(-0.022, -0.006)^a	(-0.025, -0.001)^c	(-0.032, -0.007)^b

^a p ≤ 0.001, ^b p ≤ 0.01, ^c p ≤ 0.05
P-values for the interaction term log(HDL)*2,4-D are 0.01 for all subjects, 0.005 for subjects with HbA1c > 5.1%, and 0.06 for subjects with T4 ≤ 8.5 μg/dl.

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ISSN: 1476-069X

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