Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

Schreinemachers, Dina M

doi:10.1186/1476-069X-9-11

Environmental Health

Table 6 Linear regression analysis of log(C-peptide) on 2,4-D and covariates for ages 20-59, NHANES III, 1988-1994.

From: Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

Independent variables	All available subjects (n = 706)	Susceptible subpopulations
		HbA1c > 5.1%	T4 ≤ 8.5 μg/dl
		(n = 343)	(n = 343)
	Estimate (95% CI)	Estimate (95% CI)	Estimate (95% CI)
Intercept	1.258	0.707	0.778
	(0.294, 2.221)^b	(-0.585, 1.999)	(-0.733, 2.289)
2,4-D, binary	1.567	3.599	1.733
	(-0.344, 3.478)	(0.970, 6.228)^b	(-1.078, 4.545)
Log(HDL) for 2,4-D < LOD	-0.562	-0.438	-0.558
	(-0.765, -0.358)^a	(-0.719, -0.157)^b	(-0.875, -0.241)^a
Log(HDL) for 2,4-D ≥ LOD	-0.986	-1.397	-1.029
	(-1.462, -0.509)^a	(-2.040, -0.754)^a	(-1.721, -0.336)^b
Log(urinary creatinine)	-0.013	0.018	0.029
	(-0.087, 0.062)	(-0.081, 0.116)	(-0.088, 0.147)
Gender	-0.191	-0.184	-0.167
	(-0.297, -0.086)^a	(-0.324, -0.044)^b	(-0.337, 0.004)
Age (years)	0.005	0.005	0.009
	(0.000, 0.010)^c	(-0.002, 0.011)	(0.001, 0.017)^c
Non-Hispanic Black	-0.038	-0.045	0.025
	(-0.161, 0.084)	(-0.209, 0.119)	(-0.166, 0.216)
Mexican American	0.034	0.016	0.100
	(-0.093, 0.162)	(-0.161, 0.193)	(-0.117, 0.316)
Other ethnicity	0.151	0.041	0.151
	(-0.147, 0.449)	(-0.326, 0.408)	(-0.303, 0.605)
Past smoker	-0.022	0.001	-0.048
	(-0.156, 0.112)	(-0.170, 0.173)	(-0.253. 0.156)
Active smoker	0.002	-0.043	-0.059
	(-0.108, 0.112)	(-0.189, 0.104)	(-0.235, 0.117)
BMI 25-29 kg/m²	0.480	0.480	0.607
	(0.366, 0.594)^a	(0.325, 0.636)^a	(0.431, 0.783)^a
BMI ≥ 30 kg/m²	0.890	0.858	1.067
	(0.756, 1.024)^a	(0.691, 1.025)^a	(0.849, 1.286)^a
Alcohol consumption	-0.015	-0.022	0.092
	(-0.192, 0.162)	(-0.248, 0.205)	(-0.148, 0.331)
Income ≥ 20K (%)	-0.052	0.022	0.008
	(-0.155, 0.050)	(-0.110, 0.154)	(-0.157, 0.174)
Hours of fasting	-0.008	-0.008	-0.015
	(-0.019, 0.004)	(-0.022, 0.007)	(-0.033, 0.002)

^a p ≤ 0.001, ^b p ≤ 0.01, ^c p ≤ 0.05
P-values for the interaction term log(HDL)*2,4-D are 0.10 for all subjects, 0.006 for subjects with HbA1c > 5.1%, and 0.21 for subjects with T4 ≤ 8.5 μg/dl.

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ISSN: 1476-069X

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