Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

Schreinemachers, Dina M

doi:10.1186/1476-069X-9-11

Environmental Health

Table 8 Linear regression analysis of log(TSH) on 2,4-D and covariates for ages 20-59, NHANES III, 1988-1994.

From: Perturbation of lipids and glucose metabolism associated with previous 2,4-D exposure: a cross-sectional study of NHANES III data, 1988-1994

Independent variables	All available subjects (n = 705)	Susceptible subpopulations
		HbA1c > 5.1%	T4 ≤ 8.5 μg/dl
		(n = 343)	(n = 342)
	Estimate (95% CI)	Estimate (95% CI)	Estimate (95% CI)
Intercept	-0.487	0.134	-1.263
	(-1.380, 0.407)	(-1.235, 1.503)	(-2.587, 0.061)
2,4-D, binary	1.380	-0.915	2.537^c
	(-0.395, 3.154)	(-3.689, 1.858)	(0.066, 5.007)^c
Log(HDL) for 2,4-D < LOD	0.209	0.125	0.309
	(0.021, 0.397)	(-0.172, 0.422)	(0.032, 0.585)^c
Log(HDL) for 2,4-D ≥ LOD	-0.177	0.360	-0.371
	(-0.620, 0.266)	(-0.321, 1.042)	(-0.981, 0.239)
Log(urinary creatinine)	-0.010	-0.029	0.067
	(-0.079, 0.059)	(-0.135, 0.076)	(-0.036, 0.170)
Gender	0.024	0.052	0.004
	(-0.075, 0.123)	(-0.097, 0.202)	(-0.147, 0.155)
Age (years)	0.004	0.002	0.007
	(-0.000, 0.009)	(-0.005, 0.009)	(0.000, 0.014)^c
Non-Hispanic Black	-0.264	-0.312	-0.346
	(-0.377, -0.151)^a	(-0.486, -0.138)^a	(-0.512, -0.180)^a
Mexican American	-0.126	-0.227	-0.167
	(-0.244, -0.007)^c	(-0.415, -0.040)^c	(-0.357, 0.023)
Other ethnicity	-0.046	-0.072	-0.111
	(-0.331, 0.238)	(-0.477, 0.334)	(-0.527, 0.306)
Past smoker	-0.049	-0.192	-0.076
	(-0.174, 0.076)	(-0.374, -0.010)^c	(-0.256, 0.104)
Active smoker	-0.117	-0.260	-0.080
	(-0.220, -0.014)^c	(-0.416, -0.103)^b	(-0.235, 0.075)
BMI 25-29 kg/m²	0.100	0.106	0.215
	(-0.005, 0.206)	(-0.059, 0.271)	(0.061, 0.369)^b
BMI ≥ 30 kg/m²	0.148	0.156	0.304
	(0.023, 0.274)^c	(-0.024, 0.336)	(0.111, 0.498)^b
Alcohol consumption	-0.005	0.032	-0.003
	(-0.167, 0.157)	(-0.202, 0.263)	(-0.212, 0.207)
Income ≥ 20K (%)	-0.036	-0.053	0.015
	(-0.132, 0.059)	(-0.193, 0.087)	(-0.130, 0.161)
Hours of fasting	0.002	-0.001	-0.011
	(-0.009, 0.012)	(-0.016, 0.015)	(-0.026, 0.005)

^a p ≤ 0.001, ^b p ≤ 0.01, ^c p ≤ 0.05
P-values for the interaction term log(HDL)*2,4-D are 0.10 for all subjects, 0.52 for subjects with HbA1c > 5.1%, and 0.04 for subjects with T4 ≤ 8.5 μg/dl.

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ISSN: 1476-069X

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