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Table 3 Analyses of temporal clustering of neuroblastic tumours at ages <18 months in the NRYPMDRa

From: Temporal clustering of neuroblastic tumours in children and young adults from Northern England

 

\( \widehat{\upbeta} \)b (SE)c

 

one-sided P-value d

Type of analysis

Within months

Within quarters

Within years

Within full study period

Between fortnightse

1.532 (0.866)

0.562 (0.255)

0.215 (0.082)

0.097 (0.044)

 

P = 0.038

P = 0.018

P = 0.016

P = 0.025

Between months

 

0.300 (0.387)

0.133 (0.118)

0.043 (0.062)

  

P = 0.18

P = 0.12

P = 0.18

Between quarters

  

0.214 (0.226)

−0.032 (0.108)

   

P = 0.17

P = 0.54

Between years

   

−0.403 (0.217)

    

P = 0.98

  1. a)Based on cases diagnosed during 1968–2011 inclusive
  2. b)\( \widehat{\upbeta} \) is the one-step estimate of β, the extra-Poisson variation, calculated as S/i(0) in the notation of Muirhead [42]
  3. c)SE is the standard error of \( \widehat{\upbeta} \) in the absence of extra-Poisson variation, calculated as 1/√i(0) in the notation of Muirhead [42]
  4. d)P-values have been calculated using 10000 simulations, assuming Poisson variation. All P-values are one-sided
  5. e)Cases with a diagnosis date of the 15th of the month have been excluded from the analyses between fortnights but have been included in the other analyses