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Table 4 Analyses of temporal clustering of neuroblastic tumours at ages 18 months to 24 years inclusive in the NRYPMDRa

From: Temporal clustering of neuroblastic tumours in children and young adults from Northern England

 

\( \widehat{\upbeta} \)b (SE)c

 

one-sided P-value d

Type of analysis

Within months

Within quarters

Within years

Within full study period

Between fortnightse

0.754 (0.417)

0.434 (0.145)

0.163 (0.060)

0.123 (0.044)

 

P = 0.036

P = 0.003

P = 0.008

P = 0.008

Between months

 

0.367 (0.215)

0.172 (0.084)

0.128 (0.062)

  

P = 0.046

P = 0.027

P = 0.023

Between quarters

  

0.304 (0.161)

0.143 (0.107)

   

P = 0.035

P = 0.091

Between years

   

−0.060 (0.216)

    

P = 0.56

  1. a)Based on cases diagnosed during 1968–2011 inclusive
  2. b)\( \widehat{\upbeta} \) is the one-step estimate of β, the extra-Poisson variation, calculated as S/i(0) in the notation of Muirhead [42]
  3. c)SE is the standard error of \( \widehat{\upbeta} \) in the absence of extra-Poisson variation, calculated as 1/√i(0) in the notation of Muirhead [42]
  4. d)P-values have been calculated using 10000 simulations, assuming Poisson variation. All P-values are one-sided
  5. e)Cases with a diagnosis date of the 15th of the month have been excluded from the analyses between fortnights but have been included in the other analyses