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Table 5 Analyses of temporal clustering of neuroblastic tumours at ages 0-24 years, separately for males and females in the NRYPMDRa

From: Temporal clustering of neuroblastic tumours in children and young adults from Northern England

  

\( \widehat{\upbeta} \)b (SE)c

  

one-sided P-value d

Type of analysis

 

Within months

Within quarters

Within years

Within full study period

Between fortnightse

Males

0.507 (0.423)

0.541 (0.162)

0.297 (0.063)

0.150 (0.044)

  

P = 0.12

P = 0.002

P < 0.001

P = 0.002

 

Females

2.095 (0.894)

0.157 (0.194)

0.036 (0.068)

0.005 (0.044)

  

P = 0.004

P = 0.19

P = 0.29

P = 0.39

Between months

Males

 

0.831 (0.248)

0.417 (0.089)

0.204 (0.062)

   

P < 0.001

P < 0.001

P = 0.002

 

Females

 

−0.160 (0.282)

−0.027 (0.095)

−0.058 (0.062)

   

P = 0.69

P = 0.59

P = 0.78

Between quarters

Males

  

0.508 (0.170)

0.134 (0.107)

    

P = 0.003

P = 0.10

 

Females

  

0.039 (0.181)

−0.064 (0.107)

    

P = 0.39

P = 0.68

Between years

Males

   

−0.435 (0.217)

     

P = 0.99

 

Females

   

−0.185 (0.217)

     

P = 0.79

  1. a)Based on cases diagnosed during 1968–2011 inclusive
  2. b)\( \widehat{\upbeta} \) is the one-step estimate of β, the extra-Poisson variation, calculated as S/i(0) in the notation of Muirhead [42]
  3. c)SE is the standard error of \( \widehat{\upbeta} \) in the absence of extra-Poisson variation, calculated as 1/√i(0) in the notation of Muirhead [42]
  4. d)P-values have been calculated using 10000 simulations, assuming Poisson variation. All P-values are one-sided
  5. e)Cases with a diagnosis date of the 15th of the month have been excluded from the analyses between fortnights but have been included in the other analyses