Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study

Table 4 Associations of lobular inflammation status with PFAAs at baseline^a

	Lobular Inflammation status
	None (n = 96)		<2 foci per 200x field (n = 53)			2–4 foci per 200x field (n = 11)
Compound^a	Median (ng/ml)		Median (ng/ml)	OR (95 % CI)	p-value	Median (ng/ml)	OR (95 % CI)	p-value
PFHxA	0.060	Ref	0.025	0.80 (0.38; 1.66)	0.547	0.083	0.77 (0.19; 3.03)	0.707
PFOA	2.61	Ref	2.61	0.71 (0.10; 5.18)	0.734	1.823	0.02 (<0.01; 0.66)	0.027
PFNA	0.84	Ref	0.86	0.29 (0.05; 1.61)	0.157	0.64	0.02 (<0.01; 0.53)	0.019
PFDA	0.23	Ref	0.29	1.24 (0.26; 5.90)	0.787	0.15	0.05 (<0.01; 0.83)	0.037
PFUnA	0.15	Ref	0.14	0.73 (0.29; 1.85)	0.511	0.12	0.23 (0.05; 1.15)	0.073
PFHxS	1.21	Ref	1.12	0.25 (0.03; 1.82)	0.170	0.89	0.02 (<0.01; 0.53)	0.018
PFOS	3.30	Ref	3.10	0.52 (0.13; 2.09)	0.353	2.35	0.14 (0.01; 1.66)	0.119
sumPFCA	3.96	Ref	4.04	0.49 (0.05; 4.47)	0.527	3.29	0.01 (<0.01; 0.39)	0.015
sumPFSA	4.82	Ref	4.84	0.42 (0.07; 2.57)	0.349	4.58	0.05 (0.00; 1.50)	0.083

^aConcentrations of PFAAs (ng/ml) were log-transformed for the multinomial logistic regression analysis that was adjusted for age, sex, BMI, serum lipids and fasting insulin

ISSN: 1476-069X