Rectal cancer (n = 840) | Colon cancer (n = 931) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Exposure metrica | Cases (%) | Controls (%) | ORb | (95 % CI) | Cases (%) | Controls (%) | ORb | (95 % CI) | ||||||
Ever exposed | ||||||||||||||
No | 452 | (53.8) | 783 | (57.6) | 1.00 | 505 | (54.2) | 783 | (57.6) | 1.00 | ||||
Yes | 388 | (46.2) | 577 | (42.4) | 1.12 | (0.91, | 1.38) | 426 | (45.8) | 577 | (42.4) | 1.04 | (0.85, | 1.27) |
Highest attained exposure concentration | ||||||||||||||
Unexposed | 452 | (53.8) | 783 | (57.6) | 1.00 | 505 | (54.2) | 783 | (57.6) | 1.00 | ||||
Low | 305 | (36.3) | 462 | (34.0) | 1.20 | (0.96, | 1.50) | 342 | (36.7) | 462 | (34) | 1.10 | (0.88, | 1.37) |
Medium | 55 | (6.6) | 71 | (5.2) | 1.12 | (0.73, | 1.73) | 54 | (5.8) | 71 | (5.2) | 0.92 | (0.60, | 1.42) |
High | 28 | (3.3) | 44 | (3.2) | 1.04 | (0.60, | 1.79) | 30 | (3.2) | 44 | (3.2) | 1.04 | (0.61, | 1.76) |
p-trend | 0.74 | p-trend | 0.91 | |||||||||||
Duration of exposure (years) | ||||||||||||||
Unexposed | 452 | (54.3) | 783 | (58.1) | 1.00 | 505 | (55.0) | 783 | (58.1) | 1.00 | ||||
> 0 to <7 | 117 | (14.1) | 179 | (13.3) | 1.09 | (0.82, | 1.46) | 128 | (13.9) | 161 | (11.9) | 1.00 | (0.76, | 1.34) |
≥ 7 to ≤26 | 144 | (17.3) | 196 | (14.5) | 1.20 | (0.91, | 1.59) | 141 | (15.4) | 185 | (13.7) | 0.96 | (0.73, | 1.27) |
> 26 | 120 | (14.4) | 190 | (14.1) | 1.08 | (0.77, | 1.51) | 144 | (15.7) | 219 | (16.3) | 1.10 | (0.79, | 1.51) |
p-trend | 0.33 | p-trend | 0.77 | |||||||||||
Duration of exposure at high concentration (years) | ||||||||||||||
Unexposed | 812 | (96.8) | 1316 | (97.1) | 1.00 | 901 | (97.0) | 1316 | (97.1) | 1.00 | ||||
> 0 to <5 | 15 | (1.8) | 21 | (1.6) | 1.02 | (0.48, | 2.16) | 15 | (1.6) | 21 | (1.6) | 0.94 | (0.46, | 1.94) |
≥ 5 | 12 | (1.4) | 18 | (1.3) | 1.08 | (0.48, | 2.39) | 13 | (1.4) | 18 | (1.3) | 1.13 | (0.51, | 2.52) |
p-trend | 0.84 | p-trend | 0.84 | |||||||||||
Frequency of exposure | ||||||||||||||
Unexposed | 528 | (64.6) | 852 | (66.6) | 1.00 | 582 | (63.8) | 852 | (66.6) | 1.00 | ||||
Low: 5 % | 14 | (1.7) | 56 | (4.4) | 0.46 | (0.24, | 0.89) | 32 | (3.5) | 56 | (4.4) | 0.85 | (0.51, | 1.42) |
Medium: 6–30 % | 213 | (26.0) | 282 | (22.0) | 1.08 | (0.84, | 1.40) | 224 | (24.5) | 282 | (22.0) | 1.08 | (0.84, | 1.38) |
High: >30 % | 63 | (7.7) | 90 | (7.0) | 1.00 | (0.68, | 1.48) | 75 | (8.2) | 90 | (7.0) | 1.16 | (0.80, | 1.66) |
p-trend | 0.72 | p-trend | 0.30 | |||||||||||
Cumulative occupational exposurec | ||||||||||||||
Unexposed | 452 | (54.3) | 783 | (58.0) | 1.00 | 505 | (55.0) | 783 | (58.0) | 1.00 | ||||
Lowest tertile | 117 | (14.1) | 175 | (13.0) | 1.13 | (0.84, | 1.51) | 108 | (11.8) | 144 | (10.7) | 0.85 | (0.63, | 1.15) |
Middle tertile | 140 | (16.8) | 204 | (15.1) | 1.14 | (0.86, | 1.51) | 168 | (18.3) | 217 | (16.1) | 1.13 | (0.87, | 1.48) |
Highest tertile | 124 | (14.9) | 187 | (13.9) | 1.11 | (0.81, | 1.51) | 138 | (15.0) | 205 | (15.2) | 1.06 | (0.78, | 1.43) |
p-trend | 0.38 | p-trend | 0.55 |