Low-level prenatal lead exposure and infant sensory function

Silver, Monica K.; Li, Xiaoqing; Liu, Yuhe; Li, Ming; Mai, Xiaoqin; Kaciroti, Niko; Kileny, Paul; Tardif, Twila; Meeker, John D.; Lozoff, Betsy

doi:10.1186/s12940-016-0148-6

Environmental Health

Table 3 GLM results for associations between prenatal lead and infant ABR C-P ratio^a and grating VA

From: Low-level prenatal lead exposure and infant sensory function

	Crude		Semi-adjusted^b		Fully-adjusted^c
	N	β (95 % CI)^d	N	β (95 % CI)^d	N	β (95 % CI)^d
ABR C-P ratio
Mid-pregnancy lead	304		292		292
High (>3.8 μg/dL)		0.02 (−0.00–0.05)^†		0.02 (−0.01–0.05)		0.02 (−0.01–0.05)
Med. (2–3.8 μg/dL)		0.02 (−0.01–0.05)		0.02 (−0.01–0.05)		0.02 (−0.01–0.05)
Low (<2 μg/dL); Reference		p-trend = 0.09^†		p-trend = 0.12		p-trend = 0.13
Late-pregnancy lead	315		304		304
High (>3.8 μg/dL)		0.04 (0.02–0.07)^**		0.05 (0.02–0.08)^***		0.05 (0.02–0.07)^**
Med. (2–3.8 μg/dL)		0.03 (0.00–0.05)^†		0.03 (0.01–0.06)^*		0.03 (0.00–0.06)^**
Low (<2 μg/dL); Reference		p-trend = 0.002^**		p-trend < 0.001^***		p-trend = 0.002^**
Cord lead	277		267		267
High (>3.2 μg/dL)		0.00 (−0.03–0.03)		0.00 (−0.02–0.03)		0.00 (−0.03–0.03)
Med. (2–3.2 μg/dL)		−0.00 (−0.03–0.02)		−0.00 (−0.03–0.03)		−0.00 (−0.03–0.03)
Low (<2 μg/dL); Reference		p-trend = 0.99		p-trend = 0.81		p-trend = 0.88
Grating VA
Mid-pregnancy lead	1000		990		961
High (>3.8 μg/dL)		0.00 (−0.06–0.08)		−0.03 (−0.09–0.03)		−0.02 (−0.08–0.04)
Med. (2–3.8 μg/dL)		0.02 (−0.05–0.09)		0.02 (−0.04–0.08)		0.03 (−0.03–0.09)
Low (<2 μg/dL); Reference		p-trend = 0.90		p-trend = 0.36		p-trend = 0.52
Late-pregnancy lead	1019		1016		985
High (>3.8 μg/dL)		−0.12 (−0.19--0.05)^**		−0.08 (−0.14--0.02)^*		−0.09 (−0.15--0.02)^**
Med. (2–3.8 μg/dL)		−0.08 (−0.16--0.01)^*		−0.07 (−0.13--0.01)^*		−0.07 (−0.13--0.01)^*
Low (<2 μg/dL); Reference		p-trend = 0.002^**		p-trend = 0.01^*		p-trend = 0.009^**
Cord lead	916		916		888
High (>3.2 μg/dL)		−0.02 (−0.10–0.05)		−0.03 (−0.09–0.03)		−0.03 (−0.10–0.03)
Med. (2–3.2 μg/dL)		−0.05 (−0.12–0.02)		−0.05 (−0.11–0.01)^†		−0.05 (−0.11–0.01)^†
Low (<2 μg/dL); Reference		p-trend = 0.45		p-trend = 0.25		p-trend = 0.22

^a32 ms masking condition
^bAdjusted for sex, age at testing, cord blood iron status
^cAdjusted for sex, age at testing, cord blood iron status, gestational age, birth weight, head circumference
^dEffect estimates are reported in cycles/degree for VA; ABR C-P ratio has no units (ms/ms)
† p < 0.10; * p < 0.05; ** p < 0.01; *** p < 0.001

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ISSN: 1476-069X

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