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Table 1 Suggested criteria for assessing performance of urinary biomonitoring adjustment methods

From: Assessing urinary flow rate, creatinine, osmolality and other hydration adjustment methods for urinary biomonitoring using NHANES arsenic, iodine, lead and cadmium data

Criterion

Description

Performance metric

A

Correlation between adjusted spot analyte concentrations and UFR.

Weaker correlations indicating good performance.

B

Correlation between adjusted spot analyte concentration and an independent measure of internal dose, e.g. analyte concentration in blood.

Stronger correlations indicating good performance.

C

Correlation of spot analyte concentrations with analyte excretion over 24 hr or composite 24 hr concentrations.

Closer agreement/lower variation in spot samples indicating good performance.

D

Correlation of spot analyte concentration with an independent measure of/proxy for external exposure e.g. drinking water analyte concentration.

Stronger correlations indicating good performance.

  1. Criteria A and B are used in this study