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Table 4 Association between log-transformed body burden of six PCB congeners, specified PCB functional groups, HCB and DDE, levels and NHL risk stratified by sex

From: Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study

POP by quartile

Males

Females

 

Ca/Co

OR

95% CI

P-value

p for trend

OR(adj)

95% CI

P-value

p for trend

Ca/Co

OR

95% CI

P-value

p for trend

OR(adj)

95% CI

P-value

p for trend

PCB118

47/34

1

   

1

   

31/34

1

   

1

   

35/32

0.6

(0.27,1.32)

0.202

 

0.69

(0.28,1.72)

0.424

 

35/34

1.28

(0.59,2.81)

0.534

 

1.09

(0.46,2.6)

0.846

 

22/33

0.32

(0.13,0.78)

0.013*

 

0.21

(0.07,0.65)

0.007*

 

23/34

0.89

(0.37,2.12)

0.793

 

0.69

(0.24,1.96)

0.487

 

29/33

0.39

(0.15,0.98)

0.045*

0.021*

0.4

(0.13,1.22)

0.109

0.037

48/34

2.41

(0.94,6.22)

0.068

0.138

2.09

(0.67,6.52)

0.203

0.367

PCB138

42/33

1

   

1

   

44/34

1

   

1

   

36/34

0.69

(0.34,1.38)

0.293

 

0.53

(0.22,1.25)

0.148

 

24/34

0.58

(0.29,1.13)

0.11

 

0.38

(0.17,0.87)

0.022

 

30/32

0.55

(0.24,1.27)

0.159

 

0.55

(0.2,1.54)

0.253

 

24/34

0.55

(0.25,1.19)

0.13

 

0.4

(0.16,1.02)

0.056

 

25/33

0.41

(0.17,1.03)

0.057

0.052

0.25

(0.08,0.81)

0.021*

0.033*

45/34

1.19

(0.54,2.63)

0.67

0.848

0.9

(0.33,2.47)

0.845

0.54

PCB153

42/34

1

   

1

   

47/34

1

   

1

   

38/32

0.73

(0.32,1.64)

0.444

 

0.59

(0.21,1.68)

0.324

 

19/34

0.39

(0.17,0.86)

0.02

 

0.4

(0.17,0.97)

0.041

 

30/33

0.5

(0.21,1.19)

0.115

 

0.52

(0.18,1.55)

0.243

 

28/34

0.61

(0.28,1.3)

0.198

 

0.55

(0.23,1.31)

0.175

 

23/33

0.35

(0.13,0.92)

0.034*

0.022*

0.18

(0.05,0.68)

0.011*

0.014*

43/34

0.89

(0.4,1.98)

0.774

1.00

0.68

(0.26,1.83)

0.45

0.537

PCB156

43/33

1

   

1

   

40/34

1

   

1

   

39/33

0.65

(0.31,1.36)

0.257

 

0.68

(0.27,1.76)

0.431

 

27/34

0.72

(0.34,1.51)

0.388

 

0.94

(0.41,2.18)

0.889

 

25/34

0.37

(0.15,0.9)

0.029*

 

0.34

(0.11,1.01)

0.053

 

26/34

0.69

(0.31,1.55)

0.369

 

0.8

(0.3,2.12)

0.652

 

26/32

0.42

(0.17,1.02)

0.054

0.032*

0.31

(0.1,1)

0.050*

0.021*

44/34

1.15

(0.48,2.75)

0.746

0.627

1.22

(0.42,3.52)

0.717

0.704

PCB170

39/34

1

   

1

   

41/34

1

   

1

   

38/33

0.86

(0.41,1.79)

0.679

 

0.8

(0.31,2.01)

0.629

 

28/34

0.71

(0.34,1.46)

0.347

 

0.87

(0.39,1.96)

0.737

 

27/33

0.56

(0.23,1.33)

0.185

 

0.55

(0.19,1.61)

0.275

 

28/34

0.61

(0.25,1.49)

0.283

 

0.68

(0.23,1.96)

0.473

 

29/32

0.64

(0.27,1.54)

0.321

0.217

0.38

(0.12,1.17)

0.092

0.066

40/34

0.92

(0.4,2.14)

0.854

1.00

0.94

(0.33,2.68)

0.906

0.905

PCB180

34/33

1

   

1

   

38/34

1

   

1

   

44/33

1.21

(0.57,2.55)

0.616

 

1.28

(0.47,3.44)

0.632

 

37/34

0.93

(0.44,1.96)

0.857

 

1.15

(0.48,2.77)

0.75

 

30/33

0.74

(0.31,1.72)

0.479

 

0.73

(0.25,2.15)

0.572

 

20/34

0.42

(0.17,1.06)

0.065

 

0.32

(0.1,1.03)

0.056

 

25/33

0.63

(0.26,1.53)

0.312

0.15

0.48

(0.16,1.49)

0.205

0.079

42/34

1.10

(0.46,2.66)

0.829

0.889

0.84

(0.25,2.81)

0.779

0.534

HCB

54/34

1

   

1

   

32/33

1

   

1

   

33/33

0.25

(0.09,0.69)

0.007*

 

0.25

(0.08,0.77)

0.016*

 

31/34

1.06

(0.48,2.3)

0.892

 

1.17

(0.47,2.93)

0.733

 

16/33

0.09

(0.03,0.3)

<0.001*

 

0.04

(0.01,0.21)

<0.001*

 

42/34

1.48

(0.6,3.67)

0.398

 

1.49

(0.48,4.63)

0.488

 

30/32

0.16

(0.05,0.54)

0.003

0.002*

0.07

(0.01,0.35)

0.001*

0.001*

32/34

1.14

(0.38,3.48)

0.812

0.647

1.26

(0.34,4.67)

0.731

0.688

DDE

44/33

1

   

1

   

37/34

1

   

1

   

37/33

0.64

(0.29,1.41)

0.267

 

0.46

(0.16,1.26)

0.13

 

33/34

0.82

(0.37,1.83)

0.626

 

0.53

(0.19,1.45)

0.216

 

25/34

0.37

(0.15,0.9)

0.028*

 

0.21

(0.07,0.65)

0.007*

 

35/34

0.83

(0.36,1.93)

0.672

 

0.4

(0.13,1.22)

0.107

 

27/32

0.39

(0.15,1.02)

0.054

0.031*

0.16

(0.04,0.6)

0.006*

0.003*

32/34

0.74

(0.28,1.96)

0.54

0.591

0.41

(0.11,1.46)

0.167

0.143

  1. OR – conditional logistic regression accounting for matching factors
  2. OR(adj) – conditional logistic regression additionally adjusting for BMI, height, educational level, vegetables, dairy, protein, total fat, alcohol
  3. Matched case-control pairs with incomplete information on confounders were excluded from analyses; *Significant at the 95% confidence level