Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study

Table 6 Association between exposure and risk in ‘highly exposed’ individuals high exposure is defined as exposure levels above the 90^th of the control exposure distribution, the odds of disease are compared with those in the lowest quartile of exposure

Exposure	90th percentile control exposure distribution	n cases (%) above 90^th percentile	n controls(%) above 90^th percentile	OR	95% CI	p-value	OR^(adj)	95% CI	p-value
PCB118	316.2	35(13.0)	28(10.4)	1.37	(0.76,2.45)	0.294	1.25	(0.65,2.41)	0.500
PCB138	1112.4	25(9.3)	29(10.7)	0.83	(0.45,1.52)	0.550	0.81	(0.40,1.64)	0.562
PCB153	1965.7	29(10.7)	29(10.7)	1.01	(0.56,1.81)	0.987	1.15	(0.58,2.26)	0.693
PCB156	176.4	23(8.5)	28(10.4)	0.79	(0.43,1.45)	0.447	0.89	(0.43,1.81)	0.739
PCB170	626.6	29(10.7)	29(10.7)	1.00	(0.57,1.78)	0.989	1.07	(0.55,2.06)	0.843
PCB180	1323.3	29(10.7)	28(10.4)	1.05	(0.58,1.88)	0.872	1.11	(0.57,2.14)	0.763
HCB	872.8	25(9.3)	29(10.7)	0.80	(0.41,1.55)	0.506	0.84	(0.42,1.68)	0.624
DDE	9787.7	27(10)	28(10.4)	0.95	(0.50,1.80)	0.878	1.01	(0.52,1.97)	0.978

OR – conditional logistic regression accounting for matching factors
OR^(adj) – conditional logistic regression additionally adjusting for BMI, height, educational level, vegetables, dairy, protein, total fat, alcohol
Matched case-control pairs with incomplete information on potential confounders were excluded from the adjusted analyses

ISSN: 1476-069X