Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

Table 4 Statistical significance of replicated SNPs for blood lead levels according to the univariate- or multivariate- regression models from replication analysis

SNP ID	Gene symbol	Univariate			Multivariate model 1^a			Multivariate model 2^b
SNP ID	Gene symbol	β	SE	P-value	β	SE	P-value	β	SE	P-value
rs41268474	C1orf68	0.011	0.072	0.878	0.085	0.062	0.168	0.090	0.061	0.144
rs11066280	C12orf51	−0.134	0.046	0.004	−0.170	0.040	1.94 × 10⁻⁵	−0.116	0.041	0.004
rs12229654	MYL2	−0.158	0.052	0.002	−0.184	0.044	3.46 × 10⁻⁵	−0.130	0.045	0.004
rs671	ALDH2	−0.172	0.048	3.74 × 10⁻⁴	−0.197	0.041	1.73 × 10⁻⁶	−0.139	0.043	0.001

SNPs were coded using an additive genetic model
^aAdjusted for age, sex and smoking status
^bAdjusted for age, sex, smoking status, alcohol drinking and dietary lead intake

ISSN: 1476-069X