Path | Path coefficient (95% CI) p-value | |||
---|---|---|---|---|
Lipid-adjusted | Non-lipid-adjusted | Lipid-adjusted | Non-lipid-adjusted | |
Age 60-69 | ||||
PCB 74 → DSC | 0.01 (−0.21, 0.23) | 0.001 (−0.23, 0.23) | 0.92 | 0.99 |
PCB 118 → DSC | −0.10 (−0.23, 0.25) | 0.02 (−0.23, 0.27) | 0.93 | 0.89 |
PCB 146 → DSC | −0.20 (−0.43, 0.02) | −0.21 (−0.44, 0.03) | 0.08 | 0.08 |
PCB 153 → DSC | 0.28 (0.03, 0.53) | 0.28 (0.02, 0.54) | 0.03 | 0.04 |
Lead → DSC | −0.13 (−0.28, 0.01) | −0.13 (−0.28, 0.02) | 0.07 | 0.08 |
aPIR2 → DSC | 0.16 (0.03, 0.30) | 0.16 (0.03, 0.29) | 0.02 | 0.02 |
bPIR3 → DSC | 0.33 (0.15, 0.50) | 0.33 (0.15, 0.50) | <0.001 | <0.001 |
cED2 → DSC | 0.25 (0.08, 0.42) | 0.25 (0.08, 0.42) | 0.004 | 0.003 |
dED3 → DSC | 0.28 (0.17, 0.39) | 0.28 (0.17, 0.39) | <0.001 | <0.001 |
eED4 → DSC | 0.29 (0.18, 0.40) | 0.29 (0.18, 0.41) | <0.001 | <0.001 |
fMA → DSC | −0.12 (−0.20, −0.04) | −0.12 (−0.20, −0.05) | 0.003 | 0.002 |
gOH → DSC | −0.12 (−0.26, 0.02) | −0.12 (−0.26, −0.02) | 0.09 | 0.09 |
hNHB → DSC | −0.18 (−0.25, −0.10) | −0.18 (−0.25, −0.10) | <0.001 | <0.001 |
Age → DSC | −0.13 (−0.24, −0.01) | −0.13 (−0.24, −0.01) | 0.03 | 0.03 |
Sex → DSC | 0.14 (0.05, 0.24) | 0.14 (0.04, 0.23) | 0.004 | 0.005 |
Smoke → DSC | 0.04 (−0.11, 0.19) | 0.04 (−0.11, 0.19) | 0.58 | 0.60 |
Age 70–84 (N = 248) | ||||
PCB 74 → DSC | −0.02 (−0.21, 0.18) | −0.02 (−0.22, 0.18) | 0.88 | 0.88 |
PCB 118 → DSC | −0.13 (−0.29, 0.03) | −0.13 (−0.31, 0.04) | 0.12 | 0.13 |
PCB 146 → DSC | −0.10 (−0.41, 0.21) | −0.10 (−0.44, 0.23) | 0.53 | 0.55 |
PCB 153 → DSC | 0.12 (−0.14, 0.38) | 0.13 (−0.16, 0.42) | 0.37 | 0.40 |
Lead → DSC | −0.08 (−0.20, 0.04) | −0.08 (−0.20, 0.04) | 0.19 | 0.17 |
PIR2 → DSC | 0.19 (0.03, 0.35) | 0.19 (0.02, 0.35) | 0.02 | 0.03 |
PIR3 → DSC | 0.26 (0.11, 0.42) | 0.26 (0.10, 0.41) | 0.001 | 0.001 |
ED2 → DSC | 0.25 (0.12, 0.39) | 0.25 (0.12, 0.39) | <0.001 | <0.001 |
ED3 → DSC | 0.18 (0.04, 0.32) | 0.18 (0.03, 0.32) | 0.01 | 0.02 |
ED4 → DSC | 0.30 (0.18, 0.42) | 0.31 (0.19, 0.42) | <0.001 | <0.001 |
MA → DSC | −0.11 (−0.18, −0.05) | −0.11 (−0.17, −0.05) | <0.001 | <0.001 |
OH → DSC | −0.20 (−0.32, −0.09) | −0.20 (−0.31, −0.09) | <0.001 | <0.001 |
NHB → DSC | −0.17 (−0.27, −0.07) | −0.18 (−0.27, −0.08) | <0.001 | <0.001 |
Age → DSC | −0.22 (−0.30, −0.10) | −0.20 (−0.30, −0.10) | <0.001 | <0.001 |
Sex → DSC | 0.10 (−0.04, 0.24) | 0.11 (−0.04, 0.25) | 0.15 | 0.15 |
Smoke → DSC | −0.06 (−0.18, 0.07) | −0.06 (−0.18, 0.07) | 0.35 | 0.37 |