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Table 4 Effect of bisphenol A on ovarian function

From: Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data

References

Methods

Results

Animal Data

Rodríguez et al., 2010 [46]

Neonatal exposure of mice from D1 to D7 to BPA 0.05 or 20 mg/kg/day

⇘ percentage of primordial follicles ⇗ percentages of growing follicles at 20 mg/kg/day dose by increased recruitment, ⇗ proliferation of granulosa cells at every follicular stage

Zhang et al., 2012 [45]

Exposure of pregnant mice at 0.02, 0.04 or 0.08 mg/kg/day of orally administered BPA from Day 12.5 post coïtum.

⇘ number of primordial follicles at D3 by defaults in assembly associated with. a delay in meiosis I progression ⇘ mRNA expression of specific meiotic genes

Li et al., 2014 [47]

Intraperitoneal injection of 10, 40 or 160 mg/kg of BPA in prepubertal rats for 1 week

⇘ ovary weight, ⇘ number of primordial follicles at the highest dose, dose –dependant ⇘ in numbers of total, primary/preantral and antral follicles, ⇗ number of atretic follicles

Berger et al., 2015 [44]

Exposure of pregnant mice to BPA: 0.5, 20 or 50 Î¼g/kg/day, histological analysis of ovaries and gene expression analysis at postnatal D4 and D21 from F1 to F3

Alteration in the number of follicles for F1, but not for F2 and F3. Alterations in ovarian gene expression at D21 with a transgenerational effect