Distributions and determinants of urinary biomarkers of organophosphate pesticide exposure in a prospective Spanish birth cohort study

Llop, Sabrina; Murcia, Mario; Iñiguez, Carmen; Roca, Marta; González, Llúcia; Yusà, Vicent; Rebagliato, Marisa; Ballester, Ferran

doi:10.1186/s12940-017-0255-z

Environmental Health

Table 4 Sociodemographic, environmental, and dietary characteristics associated with the OP concentrations. INMA-Valencia cohort (Spain, 2003–2006)^a

From: Distributions and determinants of urinary biomarkers of organophosphate pesticide exposure in a prospective Spanish birth cohort study

		DMTP			TCPY			sumDEP			sumDMP			sumDAP			sumOP
		beta	95% CI		beta	95% CI		beta	95% CI		beta	95% CI		beta	95% CI		beta	95% CI
Smoking habit	No
Smoking habit	Yes	−1.22**	−1.93	−0.51	−0.13	−0.78	0.53	0.19	−0.19	0.56	−0.23	−0.76	0.31	−0.53	−0.87	−0.19	−0.02	−0.42	0.39
Level of education	Primary
	Secondary	−0.40	−1.05	0.26	0.36	−0.27	0.99	0.00	−0.45	0.45	−0.23	−0.76	0.31	−0.07	−0.39	0.24	0.38*	−0.01	0.77
	University	0.27	−0.48	1.02	0.36	−0.38	1.09	0.10	−0.29	0.49	0.31	−0.30	0.93	0.13	−0.24	0.49	0.25	−0.21	0.71
Season of sampling	Winter
	Spring	−0.88*	−1.90	0.14	2.31**	1.15	3.46	−0.52*	−1.13	0.09	−0.55	−1.39	0.29	−0.25	−0.74	0.24	0.89**	0.26	1.53
	Summer	0.58	−0.33	1.48	3.26**	2.17	4.35	−0.31	−0.83	0.22	0.65*	−0.10	1.39	0.27	−0.16	0.71	1.15**	0.56	1.73
	Fall	0.74	−0.16	1.64	2.74**	1.64	3.83	0.27	−0.21	0.76	0.64*	−0.10	1.39	0.32	−0.11	0.76	0.74**	0.15	1.33
Zone of residence	Urban
	Metropolitan	−0.75	−1.69	0.18	0.15	−0.76	1.05	−0.56**	−1.06	−0.05	−0.60	−1.37	0.16	−0.37	−0.82	0.07	0.02	−0.54	0.58
	Semi-urban	−0.81	−1.80	0.18	−0.46	−1.43	0.51	−0.15	−0.66	0.36	−0.63	−1.44	0.19	−0.22	−0.70	0.25	−0.30	−0.90	0.30
	Rural	−0.58	−2.01	0.84	−0.82	−2.25	0.62	−0.33	−1.11	0.44	−0.38	−1.55	0.79	−0.15	−0.83	0.53	−0.24	−1.11	0.63
Yard with plants at home	No
Yard with plants at home	Yes	1.00**	0.23	1.76	0.64*	−0.10	1.38	−0.11	−0.57	0.35	0.76**	0.13	1.39	0.24	−0.13	0.61	0.16	−0.30	0.62
Application of outdoor pesticides	No
Application of outdoor pesticides	Yes	−0.65	−1.62	0.31	0.02	−0.91	0.94	0.55**	0.01	1.10	−0.55	−1.34	0.25	−0.12	−0.59	0.34	0.11	−0.47	0.68
Residence near fields or greenhouses	No
	Residence near fields	−0.18	−0.82	0.46	−0.22	−0.84	0.40	−0.11	−0.48	0.27	−0.22	−0.75	0.30	−0.15	−0.46	0.16	0.05	−0.33	0.44
	Residence near fields sprayed with pesticides	0.26	−0.53	1.05	0.07	−0.71	0.84	0.07	−0.37	0.50	0.12	−0.53	0.77	0.07	−0.31	0.45	0.46*	−0.01	0.93
Fruit intake (daily servings)		0.26**	0.04	0.47	0.05	−0.15	0.26	0.20**	0.09	0.31	0.21**	0.03	0.38	0.14**	0.03	0.24	0.13*	0.00	0.26
Vegetables intake (daily servings)		0.26**	0.09	0.43	0.16*	0.00	0.32	0.08	−0.01	0.17	0.23**	0.10	0.37	0.12**	0.04	0.20	0.08	−0.02	0.19
BMI before pregnancy		−0.36**	−0.67	−0.05	−0.39	−0.70	−0.08	0.02	−0.15	0.19	−0.32**	−0.58	−0.07	−0.16**	−0.31	−0.01	−0.16*	−0.35	0.02

BMI Body mass index; CI Confidence intervals; DMTP Dimethyl thiophosphate; TCPy 3,5,6-trichloro-2-pyridinol; SumDEP Sum of diethylphosphates (DEP + DETP); SumDMP Sum of dimethylphosphates (DMTP + DMDTP); SumDAP Sum of dialkyl phosphates (SumDEP + SumDMP); SumOP Sum of specific compounds (DEAMPY + IMPY + PNP + TCPY)
^aAll models were adjusted by smoking habit, educational level, season of sampling, zone of residence, yard with plants at home, application of outdoor pesticides, residence near fields or greenhouses, fruit intake, vegetable intake, BMI before pregnancy, and creatinine
*p < 0.1
**p < 0.05

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ISSN: 1476-069X

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