Table 3 Top 10 most strongly associated Human MitoCarta genes with medium-term PM10 exposure for women and men
From: Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure
Gene symbol | Gene name | FC (95% CI) | P-value | Q-value |
|---|---|---|---|---|
Women | ||||
  ALDH7A1 | aldehyde dehydrogenase 7 family member A1 | 0.70 (0.54, 0.90) | 2.36E-04 | 0.21 |
  TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 1.05 (0.97, 1.13) | 3.90E-04 | 0.21 |
  GOT2 | glutamic-oxaloacetic transaminase 2 | 0.92 (0.68, 1.24) | 8.06E-04 | 0.23 |
  PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 1.04 (0.95, 1.15) | 9.34E-04 | 0.23 |
  GLS | glutaminase | 0.79 (0.62, 1.00) | 1.40E-03 | 0.23 |
  FXN | frataxin | 0.88 (0.81, 0.97) | 1.47E-03 | 0.23 |
  HINT2 | histidine triad nucleotide binding protein 2 | 0.97 (0.88, 1.06) | 2.46E-03 | 0.23 |
  UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.97 (0.86, 1.09) | 2.56E-03 | 0.23 |
  CPT2 | carnitine palmitoyltransferase 2 | 1.03 (0.94, 1.12) | 2.59E-03 | 0.23 |
  TRUB2 | TruB pseudouridine synthase family member 2 | 0.98 (0.89, 1.07) | 3.25E-03 | 0.23 |
Men | ||||
  MRPS15 | mitochondrial ribosomal protein S15 | 1.23 (1.10, 1.38) | 1.14E-03 | 0.47 |
  CLPB | ClpB homolog, mitochondrial AAA ATPase chaperonin | 1.36 (1.15, 1.61) | 1.15E-03 | 0.47 |
  SLC25A29 | solute carrier family 25 member 29 | 1.64 (1.24, 2.16) | 1.32E-03 | 0.47 |
  BCKDK | branched chain ketoacid dehydrogenase kinase | 1.24 (1.09, 1.43) | 3.37E-03 | 0.55 |
  STOML1 | stomatin-like 1 | 1.25 (1.08, 1.44) | 4.55E-03 | 0.55 |
  ADCK1 | aarF domain containing kinase 1 | 1.33 (1.10, 1.61) | 5.22E-03 | 0.55 |
  SLC25A40 | solute carrier family 25 member 40 | 0.66 (0.50, 0.87) | 6.23E-03 | 0.55 |
  ALDH7A1 | aldehyde dehydrogenase 7 family member A1 | 1.58 (1.16, 2.16) | 6.35E-03 | 0.55 |
  MDH2 | malate dehydrogenase 2 | 1.29 (1.09, 1.54) | 6.67E-03 | 0.55 |
  ALDH1B1 | aldehyde dehydrogenase 1 family member B1 | 1.36 (1.10, 1.69) | 7.33E-03 | 0.55 |