From: Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure
 | Pathway | Effective/ total size | # ↓ genes | Contributing genes (#)§ | P-value |
---|---|---|---|---|---|
Women | |||||
 |  RNA Polymerase I Chain Elongation | 79/98 | 25 | HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑;POLR1E↓(24) | 1.7E-04 |
 |  Meiosis | 63/77 | 20 | HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑; HIST1H4I↑(20) | 3.0E-04 |
 |  RMTs methylate histone arginines | 64/74 | 23 | HIST2H2A↑;RBBP7↓;HIST1H2A↑;HIST1H2A↑; HIST1H4E↑(20) | 3.8E-04 |
 |  RNA Polymerase I Transcription | 100/121 | 35 | HIST2H2A↑;RBBP7↓;HIST1H2A↑;HIST1H4E↑; HIST1H2A↑(27) | 5.7E-04 |
 |  Mitochondrial translation (termination)* | 84/85 | 25 | MRPL50 ↓; MRPL22 ↑; MRPL30 ↑; MRPL47 ↑; MRPL54↑ (23) | 1.1E-03 |
 |  phospholipids as signalling intermediaries | 30/36 | 12 | EDG1↓;MAP2K1↓;ITGAV↓;SOS1↑;SRC↑;PDGFA↑;PIK3CA↓;ASAH1↑;PDPK1↑;HRAS↑;ADCY1↓(11) | 1.9E-03 |
 |  Meiotic recombination | 53/64 | 15 | HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑;HIST1H4I↑(16) | 2.1E-03 |
 |  Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.* | 99/113 | 23 | UQCRH ↑; ATP5L ↓; NDUFA13 ↑; COX7C ↑; UCP3↑ (25) | 2.5E-03 |
 |  Meiotic synapsis | 40/48 | 8 | HIST1H4E↑;HIST1H4I↑;HIST1H2A↑;HIST4H4↑;RAD21↓;HIST1H4H↑;ATR↓;HIST2H4B↑;HIST1H4J↑;BRCA1↑;HIST1H4K↑;REC8L1↑; HIST1H2B↑(13) | 2.6E-03 |
 |  Sirtuin 1 negatively regulates rRNA Expression | 59/76 | 18 | HIST1H4H↑;HIST2H2A↑;HIST1H4I↑;HIST1H2A↑; HIST1H2A↑(17) | 2.7E-03 |
 |  Condensation of Prophase Chromosomes | 64/77 | 17 | HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑; HIST1H4I↑(18) | 2.8E-03 |
 |  NoRC negatively regulates rRNA expression | 95/116 | 34 | HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑; POLR1E↓(24) | 3.0E-03 |
 |  RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | 133/159 | 48 | HIST2H2A↑;RBBP7↓;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑(31) | 3.2E-03 |
 |  Platelet Aggregation (Plug Formation) | 28/38 | 9 | GP1BA↑;SOS1↑;SRC↑;VWF↑;RASGRP2↓;GP9↑;ITGA2B↑;PDPK1↑; TLN1↑;RAP1A↓(10) | 3.7E-03 |
 |  Respiratory electron transport* | 81/92 | 17 | UQCRH ↑; NDUFA13 ↑; COX7C ↑; FAM36A ↑; NDUFA6↑ (21) | 3.8E-03 |
Men | |||||
 |  3-phosphoinositide biosynthesis | 25/29 | 10 | C17orf38↑;PIK4CB↑;PIK3R1↑;PIP5K3↓;PIK4CA ↑; CDIPT↑; PIP5K2B↑;PIK3R2↑(8) | 2.0E-04 |
 |  superpathway of inositol phosphate compounds | 62/71 | 31 | C17orf38↑;PIK4CB↑;PIK3R1↑;TMEM55A↓;PIP5K3↓;IHPK2↑;SKIP↑; PIK4CA ↑; CDIPT↑;PIP5K2B↑;PIK3R2↑;OCRL↓;HISPPD1↓(13) | 2.8E-04 |
 |  TCA cycle* | 27/34 | 7 | MDH2 ↑; IDH2 ↑; IDH3G ↑; SUCLA2 ↑; SDHA ↑; CLYBL ↑; PCK2 ↑; ACO2↑ (8) | 3.7E-04 |
 |  Citrate cycle (TCA cycle)* | 28/30 | 9 | MDH2 ↑; IDH2 ↑; PC ↑; IDH3G ↑; SUCLA2 ↑; SDHA ↑; PCK2 ↑; ACO2↑ (8 ) | 4.8E-04 |
 |  PI Metabolism | 47/53 | 19 | C17orf38↑;PIK4CB↑;PIK3R1↑;PIP5K3↓;SKIP↑;PIK4CA↑;PIP5K2B↑;ARF1↑;PIK3R2↑;OCRL↓(10) | 1.3E-03 |
 |  IRS-related events triggered by IGF1R | 74/93 | 26 | GBL↑;MAP2K2↑;FGFR4↑;IGF2↑;STK11↑;PIK3R1↑;DOK1↑; FGF4↑;AKT2↑;TYK2↑;PIK3R2↑;TLR9↓;SOS1↓(13) | 1.7E-03 |
 |  Warburg Effect* | 43/45 | 15 | PC ↑; IDH3G ↑; GAPDH ↑; SLC1A5↑;SDHA ↑; ENO1↑;PKM2↑;ACO2 ↑; PGD↑(9) | 2.5E-03 |
 |  Synthesis of PIPs at the Golgi membrane | 15/20 | 6 | PIK4CB↑;PIP5K3↓;PIK4CA↑;ARF1↑;OCRL↓(5) | 2.7E-03 |
 |  superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle | 44/52 | 13 | MDH2↑;GCK↑;IDH3G↑;GAPDH↑;SUCLA2↑;SDHA↑;ENO1↑;PKM2↑; ACO2↑(9) | 2.9E-03 |
 |  Histidine metabolism | 23/36 | 7 | ALDH7A1 ↑; ALDH1B1 ↑; SLC38A5↑;SLC1A4↑;SLC1A5↑; SLC38A3↑(6) | 4.1E-03 |
 |  Ghrelin | 31/44 | 7 | PIK3R1↑;DOK1↑;AP2M1↑;NOS3↑;GNAI2↑;PRKCE↓; RICTOR↓(7) | 4.7E-03 |
 |  IL6 signaling pathway | 39/43 | 9 | MAP2K2↑;PIK3R1↑;HCK↑;NR2F6↑;TYK2↑;PIK3R2↑;BCL2L1 ↑; SOS1↓(7) | 4.8E-03 |
 |  Cell-Cell communication | 95/130 | 29 | PIK3R1↑;ACTN4↑;PARD6G↑;ACTN3↑;PAK1↑;SIRPG↑;KIRREL2↑; DSCAM↑;CDH24↑;PIK3R2↑;CDH3↑;CLDN23↑;CLDN3↑;FLNC↑(14) | 6.0E-03 |
 |  Regulation of toll-like receptor signaling pathway | 116/142 | 38 | GBL↑;MAP2K2↑;PIK3R1↑;IKBKE↑;SQSTM1↑(16) | 6.6E-03 |
 |  Downstream signaling of activated FGFR | 127/155 | 46 | CDKN1A↑;GBL↑;MAP2K2↑;FGFR4↑;PIK3R1↑(17) | 7.0E-03 |