Skip to main content

Table 5 Top 15 significant pathways associated with medium-term exposure

From: Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure

 

Pathway

Effective/ total size

# ↓ genes

Contributing genes (#)§

P-value

Women

 

 RNA Polymerase I Chain Elongation

79/98

25

HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑;POLR1E↓(24)

1.7E-04

 

 Meiosis

63/77

20

HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑; HIST1H4I↑(20)

3.0E-04

 

 RMTs methylate histone arginines

64/74

23

HIST2H2A↑;RBBP7↓;HIST1H2A↑;HIST1H2A↑; HIST1H4E↑(20)

3.8E-04

 

 RNA Polymerase I Transcription

100/121

35

HIST2H2A↑;RBBP7↓;HIST1H2A↑;HIST1H4E↑; HIST1H2A↑(27)

5.7E-04

 

 Mitochondrial translation (termination)*

84/85

25

MRPL50 ↓; MRPL22 ↑; MRPL30 ↑; MRPL47 ↑; MRPL54↑ (23)

1.1E-03

 

 phospholipids as signalling intermediaries

30/36

12

EDG1↓;MAP2K1↓;ITGAV↓;SOS1↑;SRC↑;PDGFA↑;PIK3CA↓;ASAH1↑;PDPK1↑;HRAS↑;ADCY1↓(11)

1.9E-03

 

 Meiotic recombination

53/64

15

HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑;HIST1H4I↑(16)

2.1E-03

 

 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.*

99/113

23

UQCRH ↑; ATP5L ↓; NDUFA13 ↑; COX7C ↑; UCP3↑ (25)

2.5E-03

 

 Meiotic synapsis

40/48

8

HIST1H4E↑;HIST1H4I↑;HIST1H2A↑;HIST4H4↑;RAD21↓;HIST1H4H↑;ATR↓;HIST2H4B↑;HIST1H4J↑;BRCA1↑;HIST1H4K↑;REC8L1↑; HIST1H2B↑(13)

2.6E-03

 

 Sirtuin 1 negatively regulates rRNA Expression

59/76

18

HIST1H4H↑;HIST2H2A↑;HIST1H4I↑;HIST1H2A↑; HIST1H2A↑(17)

2.7E-03

 

 Condensation of Prophase Chromosomes

64/77

17

HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑; HIST1H4I↑(18)

2.8E-03

 

 NoRC negatively regulates rRNA expression

95/116

34

HIST2H2A↑;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑; POLR1E↓(24)

3.0E-03

 

 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

133/159

48

HIST2H2A↑;RBBP7↓;HIST1H2A↑;HIST1H4E↑;HIST1H2A↑(31)

3.2E-03

 

 Platelet Aggregation (Plug Formation)

28/38

9

GP1BA↑;SOS1↑;SRC↑;VWF↑;RASGRP2↓;GP9↑;ITGA2B↑;PDPK1↑; TLN1↑;RAP1A↓(10)

3.7E-03

 

 Respiratory electron transport*

81/92

17

UQCRH ↑; NDUFA13 ↑; COX7C ↑; FAM36A ↑; NDUFA6↑ (21)

3.8E-03

Men

 

 3-phosphoinositide biosynthesis

25/29

10

C17orf38↑;PIK4CB↑;PIK3R1↑;PIP5K3↓;PIK4CA ↑; CDIPT↑; PIP5K2B↑;PIK3R2↑(8)

2.0E-04

 

 superpathway of inositol phosphate compounds

62/71

31

C17orf38↑;PIK4CB↑;PIK3R1↑;TMEM55A↓;PIP5K3↓;IHPK2↑;SKIP↑; PIK4CA ↑; CDIPT↑;PIP5K2B↑;PIK3R2↑;OCRL↓;HISPPD1↓(13)

2.8E-04

 

 TCA cycle*

27/34

7

MDH2 ↑; IDH2 ↑; IDH3G ↑; SUCLA2 ↑; SDHA ↑; CLYBL ↑; PCK2 ↑; ACO2↑ (8)

3.7E-04

 

 Citrate cycle (TCA cycle)*

28/30

9

MDH2 ↑; IDH2 ↑; PC ↑; IDH3G ↑; SUCLA2 ↑; SDHA ↑; PCK2 ↑; ACO2↑ (8 )

4.8E-04

 

 PI Metabolism

47/53

19

C17orf38↑;PIK4CB↑;PIK3R1↑;PIP5K3↓;SKIP↑;PIK4CA↑;PIP5K2B↑;ARF1↑;PIK3R2↑;OCRL↓(10)

1.3E-03

 

 IRS-related events triggered by IGF1R

74/93

26

GBL↑;MAP2K2↑;FGFR4↑;IGF2↑;STK11↑;PIK3R1↑;DOK1↑; FGF4↑;AKT2↑;TYK2↑;PIK3R2↑;TLR9↓;SOS1↓(13)

1.7E-03

 

 Warburg Effect*

43/45

15

PC ↑; IDH3G ↑; GAPDH ↑; SLC1A5↑;SDHA ↑; ENO1↑;PKM2↑;ACO2 ↑; PGD↑(9)

2.5E-03

 

 Synthesis of PIPs at the Golgi membrane

15/20

6

PIK4CB↑;PIP5K3↓;PIK4CA↑;ARF1↑;OCRL↓(5)

2.7E-03

 

 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle

44/52

13

MDH2↑;GCK↑;IDH3G↑;GAPDH↑;SUCLA2↑;SDHA↑;ENO1↑;PKM2↑; ACO2↑(9)

2.9E-03

 

 Histidine metabolism

23/36

7

ALDH7A1 ↑; ALDH1B1 ↑; SLC38A5↑;SLC1A4↑;SLC1A5↑; SLC38A3↑(6)

4.1E-03

 

 Ghrelin

31/44

7

PIK3R1↑;DOK1↑;AP2M1↑;NOS3↑;GNAI2↑;PRKCE↓; RICTOR↓(7)

4.7E-03

 

 IL6 signaling pathway

39/43

9

MAP2K2↑;PIK3R1↑;HCK↑;NR2F6↑;TYK2↑;PIK3R2↑;BCL2L1 ↑; SOS1↓(7)

4.8E-03

 

 Cell-Cell communication

95/130

29

PIK3R1↑;ACTN4↑;PARD6G↑;ACTN3↑;PAK1↑;SIRPG↑;KIRREL2↑; DSCAM↑;CDH24↑;PIK3R2↑;CDH3↑;CLDN23↑;CLDN3↑;FLNC↑(14)

6.0E-03

 

 Regulation of toll-like receptor signaling pathway

116/142

38

GBL↑;MAP2K2↑;PIK3R1↑;IKBKE↑;SQSTM1↑(16)

6.6E-03

 

 Downstream signaling of activated FGFR

127/155

46

CDKN1A↑;GBL↑;MAP2K2↑;FGFR4↑;PIK3R1↑(17)

7.0E-03

  1. # ↓ Number of down-regulated genes. § If more than 15 contributing genes only the top 5 is given. Mitochondrial pathways are marked with an asterisk and MitoCarta genes are indicated in bold type. RMTs: arginine methyltransferases; IGF1R: insulin-like growth factor 1; FGFR: fibroblast growth factor receptors