A prospective study of cancer risk among Agricultural Health Study farm spouses associated with personal use of organochlorine insecticides

Louis, Lydia M.; Lerro, Catherine C.; Friesen, Melissa C.; Andreotti, Gabriella; Koutros, Stella; Sandler, Dale P.; Blair, Aaron; Robson, Mark G.; Beane Freeman, Laura E.

doi:10.1186/s12940-017-0298-1

Environmental Health

Table 2 RR and CIs^b for ever versus never use of OC insecticides, for all cancer sites^±

From: A prospective study of cancer risk among Agricultural Health Study farm spouses associated with personal use of organochlorine insecticides

	N _total	Any OC^a			Chlordane			DDT			Lindane			Aldrin			Heptachlor			Toxaphene			Dieldrin
	N _total	N _exposed	RR	95% CI	N _exposed	RR	95% CI	N _exposed	RR	95% CI	N _exposed	RR	95% CI	N _exposed	RR	95% CI	N _exposed	RR	95% CI	N _exposed	RR	95% CI	N _exposed	RR	95% CI
All Cancer Sites^c	3,204	287	0.96	0.85–1.08	160	0.99	0.84–1.16	158	0.98	0.83–1.15	46	0.91	0.68–1.22	41	1.12	0.82–1.53	36	1.06	0.76–1.48	29	1.05	0.73–1.52	17	1.02	0.63–1.65
Solid tumors
Bladder	103	4	0.64	0.23–1.77	1	_	_	3	0.83	0.26–2.67	1	_	_	0	_	_	0	_	_	1	_	_	0	_	_
Colon	236	28	1.19	0.80–1.75	18	1.42	0.87–2.32	16	1.17	0.70–1.95	3	0.79	0.25–2.49	6	1.73	0.76–3.91	4	1.24	0.46–3.36	3	1.31	0.42–4.12	4	2.41	0.89–6.53
Glioma	44	11	3.52	1.72–7.21	4	1.81	0.64–5.12	2	_	_	3	4.45	1.36–14.55	1	_	_	2	_	_	2	_	_	0	_	_
Kidney	71	6	0.89	0.38–2.08	3	0.85	0.26–2.72	5	1.41	0.56–3.57	0	_	_	1	_	_	0	_	_	2	_	_	0	_	_
Lung	203	15	0.70	0.41–1.20	10	0.90	0.47–1.71	10	0.84	0.44–1.59	2	_	_	2	_	_	1	_	_	5	2.13	0.87–5.21	2	_	_
Melanoma (cutaneous)	145	12	1.08	0.59–1.97	4	0.63	0.23–1.72	5	0.88	0.36–2.18	2	_	_	3	2.20	0.69–7.02	3	2.40	0.75–7.64	1	_	_	1	_	_
Pancreas	55	7	1.33	0.59–2.97	3	1.03	0.32–3.34	1	_	_	3	3.70	1.15–12.0	1	_	_	1	_	_	0	_	_	0	_	_
Rectum	69	8	1.27	0.60–2.70	6	1.80	0.77–4.21	6	1.79	0.76–4.22	0	_	_	1	_	_	1	_	_	1	_	_	0	_	_
Stomach	26	5	2.61	0.96–7.11	1	_	_	3	2.64	0.76–9.15	1	_	_	1	_	_	0	_	_	0	_	_	0	_	_
Thyroid	54	5	0.66	0.26–1.63	4	0.97	0.36–2.67	1	_	_	0	_	_	1	_	_	1	_	_	0	_	_	0	_	_
Lymphohematopoietic malignancies
NHL	233	28	1.23	0.82–1.83	17	1.35	0.82–2.22	17	1.35	0.81–2.22	6	1.60	0.71–3.60	1	_	_	3	1.03	0.33–3.24	3	1.49	0.48–4.68	0	_	_
Multiple Myeloma	42	8	2.01	0.91–4.42	6	2.71	1.12–6.55	4	1.75	0.61–5.01	1	_	_	0	_	_	1	_	_	1	_	_	0	_	_
Myeloid Leukemia	34	4	1.26	0.44–3.65	3	1.82	0.55–6.09	3	1.66	0.49–5.56	0	_	_	0	_	_	1	_	_	0	_	_	0	_	_
Female specific sites
Breast	1,214	99	0.89	0.72–1.09	56	0.93	0.71–1.22	52	0.89	0.67–1.18	17	0.88	0.54–1.42	11	0.88	0.48–1.59	11	0.93	0.51–1.68	5	0.49	0.20–1.18	6	1.06	0.48–2.38
ER + PR+	736	64	0.94	0.73–1.23	36	0.98	0.70–1.37	33	0.93	0.65–1.33	9	0.75	0.39–1.45	8	1.00	0.50–2.02	8	1.05	0.52–2.11	2	_	_	3	0.83	0.27–2.60
ER-PR-	202	15	0.82	0.48–1.40	9	0.90	0.46–1.76	7	0.76	0.36–1.63	4	1.22	0.45–3.30	2	_	_	2	_	_	1	_	_	3	3.55	1.12–11.18
ER + PR-	125	8	0.65	0.32–1.35	5	0.78	0.32–1.92	4	0.61	0.22–1.67	2	_	_	0	_	_	0	_	_	1	_	_	0	_	_
Ovarian	106	9	0.65	0.30–1.61	7	1.05	0.40–2.89	5	0.77	0.20–2.46	2	_	_	2	_	_	2	_	_	1	_	_	1	_	_
Uterine	276	20	0.83	0.50–1.32	10	0.80	0.40–1.50	10	0.82	0.42–1.56	2	_	_	4	1.50	0.60–4.06	3	1.12	0.40–3.51	2	_	_	1	_	_

Significant Findings are listed in boldface
AHS Agricultural Health Study, RR relative risks, OC organochlorines, ER estrogen receptor, PR progesterone receptor
^± n ≥ 3 exposed cases
^aEver use of any of the seven OC insecticides
^bAdjusted for age, education, state of residence, pack-years smoked, and alcohol consumption
^cInclusive of all reported cancer sites

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ISSN: 1476-069X

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