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Table 2 Menarche hazard ratio (95% CI) associated with log(ng/ml) increase in each EDC biomarker across puberty

From: Childhood and adolescent phenol and phthalate exposure and the age of menarche in Latina girls

Biomarker

Unadjusted Model

Adjusted Modela

Interaction with Tanner stageb

Interaction with BMIc

2,4-Dichlorophenol

0.98 (0.87, 1.10)

1.00 (0.89, 1.12)

0.246

0.062

2,5-Dichlorophenol

1.05 (0.97, 1.14)

1.04 (0.95, 1.14)

0.017*

0.975

Benzophenone-3

1.03 (0.97, 1.09)

1.05 (0.99, 1.11)

0.009**

0.235

BPA

0.90 (0.78, 1.05)

0.92 (0.79, 1.06)

0.362

0.790

MBP

0.95 (0.84, 1.07)

0.96 (0.85, 1.08)

0.565

0.396

MBzP

0.98 (0.87, 1.09)

0.94 (0.84, 1.05)

0.729

0.891

MCNP

0.95 (0.82, 1.10)

0.91 (0.79, 1.05)

0.392

0.797

MCOP

0.95 (0.81, 1.10)

0.92 (0.78, 1.09)

0.638

0.790

MCPP

0.91 (0.80, 1.04)

0.91 (0.79, 1.05)

0.157

0.252

ΣDEHPd

1.04 (0.88, 1.22)

1.02 (0.87, 1.19)

0.002**

0.783

MECPP

1.05 (0.89, 1.24)

1.02 (0.87, 1.20)

0.004**

0.855

MEHHP

1.03 (0.89, 1.18)

1.01 (0.88, 1.16)

0.002**

0.643

MEHP

1.01 (0.85, 1.20)

1.01 (0.85, 1.20)

0.000***

0.909

MEOHP

1.02 (0.88, 1.19)

1.01 (0.87, 1.16)

0.004**

0.852

MEP

1.10 (0.99, 1.23)

1.09 (0.98, 1.21)

0.177

0.033*

Methyl Paraben

1.00 (0.94, 1.07)

1.00 (0.94, 1.07)

0.861

0.576

MHBP

1.02 (0.89, 1.16)

1.02 (0.89, 1.17)

0.486

0.488

MHiBP

1.04 (0.88, 1.23)

1.04 (0.88, 1.24)

0.426

0.920

MiBP

1.02 (0.87, 1.19)

1.01 (0.86, 1.19)

0.955

0.671

MMP

1.05 (0.93, 1.19)

1.08 (0.97, 1.22)

0.017*

0.262

Propyl Paraben

0.99 (0.92, 1.05)

0.99 (0.93, 1.05)

0.495

0.160

Triclosan

0.98 (0.90, 1.07)

1.00 (0.92, 1.08)

0.956

0.033*

  1. aAccelerated failure time model adjusting for BMI Z-score, and maternal education
  2. bp-value for interaction between continuous biomarker concentration and Tanner stage at biomarker measurement in adjusted models
  3. cp-value for interaction between continuous biomarker concentration and BMI Z-score in adjusted models
  4. dunits in log(nmol/l) reflecting the log transformed summation of DEHP metabolite concentrations
  5. *p < 0.05, **p < 0.01, ***p < 0.001