Trimester-specific phthalate concentrations and glucose levels among women from a fertility clinic

Table 2 Distribution of SG-adjusted trimester specific urinary phthalate metabolites measured during pregnancy among 245 women¹ from EARTH study

Phthalate metabolites	Trimester	Number	Detection frequency²	SG-adjusted concentrations
Phthalate metabolites	Trimester	Number	Detection frequency²	geometric (SD)	min	25th	50th	75th	95th	max
MEP (ng/mL)	1	208	100%	43.6 (4.4)	3.33	15.3	31.96	96.54	586.74	12,600
MEP (ng/mL)	2	209	100%	60.2 (6.1)	2.96	21.99	47.99	144.2	1024	4791
MBP (ng/mL)	1	208	99.5%	10.9 (0.6)	<LOD	6.61	10.47	16.21	40.37	2186
MBP (ng/mL)	2	209	97.6%	11.8 (0.9)	<LOD	6.83	11.95	21	64.52	1699
MiBP (ng/mL)	1	208	96.6%	5.7 (0.3)	<LOD	3.45	5.82	9.97	19.6	52.85
MiBP (ng/mL)	2	209	97.6%	5.7 (0.4)	<LOD	3.29	6.16	10.11	24.36	152.35
MBzP (ng/mL)	1	208	95.7%	3.0 (0.2)	<LOD	1.51	2.87	5.02	18.2	285.06
MBzP (ng/mL)	2	209	91.9%	2.9 (0.2)	<LOD	1.41	2.8	5.37	26.21	369.6
MCPP (ng/mL)	1	208	98.1%	4.9 (0.5)	<LOD	1.67	3.81	12.52	77.78	651.72
MCPP (ng/mL)	2	209	96.7%	3.7 (0.3)	<LOD	1.69	2.9	6.46	45.13	486.5
MCOP (ng/mL)	1	192	97.9%	28.2 (2.9)	<LOD	10.46	28.28	76.39	322	687.27
MCOP (ng/mL)	2	190	97.4%	21.9 (2.3)	<LOD	7.7	20.38	60.39	322	659.17
MCNP (ng/mL)	1	192	93.2%	4.2 (0.3)	<LOD	1.87	3.36	7.66	29.65	239
MCNP (ng/mL)	2	190	92.6%	3.5 (0.3)	<LOD	1.75	2.99	6.3	30.05	209.07
∑DEHP(nmol/mL)	1	208		0.2 (0.02)	0.02	0.09	0.15	0.36	2.71	17.89
∑DEHP(nmol/mL)	2	209		0.1 (0.01)	0.01	0.07	0.12	0.23	1.5	8.21

Abbreviations: min minimum, max maximum, SG specific gravity, N number of women = number of urine samples, MEP monoethyl phthalate, MBP mono-n-butyl phthalate, MiBP mono-isobutyl phthalate, MBzP monobenzyl phthalate, MCPP mono-3(carboxypropyl) phthalate, MCOP monocarboxyisooctyl phthalate, MCNP monocarboxyisononyl phthalate, DEHP di-2(ethylhexyl) phthalate
¹Of 245 women, 208 women provided 1st trimester urine sample, and 209 women provided 2nd trimester urine sample.
²Percent of phthalate metabolite concentrations above the limits of detection (LODs). LODs were 0.4–0.8 μg/L for MEP; 0.4–0.6 μg/L for MBP; 0.2–0.3 μg/L for MiBP; 0.2–0.3 μg/L for MBzP; 0.1–0.2 μg/L for MCPP; 0.2–0.7 μg/L for MCOP; 0.2–0.6 μg/L for MCNP; 0.5–1.2 μg/L for MEHP, 0.2–0.7 μg/L for MEHHP and MEOHP; and 0.2–0.6 μg/L for MECPP.

ISSN: 1476-069X