Changes in plasma levels of perfluoroalkyl substances (PFASs) are related to increase in carotid intima-media thickness over 10 years – a longitudinal study

Table 4 Relationships between changes in plasma levels of eight PFAS over 10 years and change in IMT over 10 years. Both the PFASs and IMT were measured at age 70, 75, and 80 years. All models were adjusted for sex. In the multiple adjusted models, additional adjustment was performed for HDL and LDL cholesterol, smoking, systolic blood pressure, statin use, BMI, fasting glucose and serum triglycerides at the three time points

	Beta	SE	z	p-value	[95% Conf. Interval]	Change in IMT for an IQR change in the PFAS
PFHpA sex-adjusted	0.010	0.003	3.05	0.0023	0.004–0.017
PFHpA multiple-adjusted	0.011	0.003	3.13	0.0017	0.004–0.017	0.016
PFHxS sex-adjusted	0.014	0.005	2.77	0.0057	0.004–0.024
PFHxS multiple-adjusted	0.015	0.005	2.99	0.0028	0.005–0.025	0.012
PFOS sex-adjusted	0.011	0.005	2.35	0.019	0.002–0.020
PFOS multiple-adjusted	0.011	0.005	2.35	0.019	0.002–0.020	0.0056
PFOA sex-adjusted	0.021	0.006	3.29	0.0010	0.008–0.033
PFOA multiple-adjusted	0.021	0.006	3.23	0.0012	0.008–0.033	0.0088
PFNA sex-adjusted	0.016	0.006	2.68	0.0074	0.004–0.028
PFNA multiple-adjusted	0.017	0.006	2.69	0.0072	0.005–0.028	0.0077
PFDA sex-adjusted	0.020	0.007	2.93	0.0034	0.007–0.033
PFDA multiple-adjusted	0.020	0.007	2.89	0.0038	0.006–0.033	0.0089
PFOSA sex-adjusted	0.011	0.004	2.84	0.0045	0.004–0.020
PFOSA multiple-adjusted	0.020	0.004	3.06	0.0022	0.005–0.021	0.016
PFUnDA sex-adjusted	0.022	0.007	3.10	0.0020	0.008–0.036
PFUnDA multiple-adjusted	0.023	0.007	3.26	0.0011	0.009–0.037	0.011

Ln-transformed values for the PFASs are used in the models. The column at the far right shows the change in IMT (mm) that corresponds to a one interquartile range (IQR) change in the PFAS (just given to the multiple adjusted models
PFASs: PFHpA perfluoroheptanoic acid, PFHxS perfluorohexane sulfonic acid, PFOS perfluorooctane sulfonic acid, PFOA perfluorooctane sulfonic acid, PFNA perfluorononanoic acid, PFDA perfluorodecanoic acid, PFOSA perfluorooctane sulfonamide, PFUnDA perfluoroundecanoic acid

ISSN: 1476-069X