Breast cancer risk and serum levels of per- and poly-fluoroalkyl substances: a case-control study nested in the California Teachers Study

Table 2 Serum Concentration of PFAS (ng/mL) among breast cancer cases and controls

	n	DF	LOD	Mean^b	Median^b	Min^b	Max^b	p-value^c
PFOA (Perfluorooctanoic acid)
Cases	902	99.8	0.073	2.744	2.350	0.042	39.100
Controls	858	100.0	0.077	2.938	2.475	0.096	20.200	0.12
PFNA (Perfluorononanoic acid)
Cases	871^a	99.0	0.029	0.987	0.850	0.017	7.310
Controls	849	98.8	0.032	1.036	0.846	0.017	10.400	0.96
PFUnDA (Perfluoroundecanoic acid)
Cases	902	94.5	0.016	0.155	0.122	0.007	1.030
Controls	858	95.5	0.018	0.163	0.128	0.007	1.310	0.22
PFHxS (Perfluorohexane sulfonic acid
Cases	902	99.8	0.022	2.217	1.515	0.011	40.700
Controls	858	99.9	0.018	2.242	1.605	0.011	21.800	0.16
PFOS (Perfluorooctane sulfonic acid)
Cases	902	99.8	0.063	8.021	6.695	0.046	39.400
Controls	858	99.4	0.078	8.320	6.950	0.046	99.800	0.14
MeFOSAA (2-(N-Methyl-perfluorooctane sulfonamido) acetic acid)
Cases	902	94.4	0.018	0.301	0.152	0.007	4.000
Controls	858	94.8	0.019	0.331	0.173	0.006	8.370	0.04
EtFOSSA (2-(N-Ethyl-perfluorooctane sulfonamido) acetic acid)
Cases	902	68.4	0.013	–	–	–	–
Controls	858	71.3	0.015	–	–	–	–	–
PFBS (Perfluorobutane sulfonic acid)
Cases	138^a	8.0	0.053	–	–	–	–
Controls	294	17.7	0.043	–	–	–	–	–
PFDA (Perfluorodecanoic acid)
Cases	902	87.3	0.061	–	–	–	–
Controls	858	88.7	0.053	–	–	–	–	–
PFDoDA (Perfluorododeconic acid)
Cases	880^a	8.6	0.096	–	–	–	–
Controls	858	7.5	0.099	–	–	–	–	–
PFHpA (Perfluoroheptanoic acid)
Cases	902	64.3	0.028	–	–	–	–
Controls	858	62.6	0.030	–	–	–	–	–
PFOSA (Perfluorooctane sulfonamide)
Cases	672^a	51.6	0.023	–	–	–	–
Controls	775	65.2	0.019	–	–	–	–	–

DF detection frequency, LOD average limit of detection, Min minimum, Max maximum
^a Due to laboratory failure 40 PFNA, 1328 PFBS, 22 PFDoA, and 313 PFOSA sample concentrations were not reported
^b Descriptive statistics were not generated for the PFASs excluded from analysis due to DF < 95%
^cp-value from the Wilcoxon rank sum test for differences in medians by case-control status

ISSN: 1476-069X