PFAS Serum Concentration | Postmenopausal (n = 1657) | Pre- or Peri-menopausal (n = 102) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
# cases | Crude Odds Ratio (OR) b | Adjusted Odds Ratio (OR) d | # cases | Crude Odds Ratio (OR) b | Adjusted Odds Ratio (OR) e | |||||
OR (95% CI) | p-valuec | OR (95% CI) | p-valuec | OR (95% CI) | p-valuec | OR (95% CI) | p-valuec | |||
PFOA | ||||||||||
 Low | 306 | 1.00 | 0.27 | 1.00 | 0.49 | 25 | 1.00 | 0.77 | 1.00 | 0.62 |
 Medium | 287 | 0.868 (0.682, 1.103) | 0.889 (0.689, 1.147) | 11 | 0.881 (0.318, 2.443) | 0.888 (0.239, 3.302) | ||||
 High | 266 | 0.870 (0.679, 1.116) | 0.912 (0.699, 1.189) | 7 | 0.859 (0.264, 2.796) | 0.669 (0.143, 3.119) | ||||
 log [PFOA, ng/mL] | 859 | 0.696 (0.475, 1.019) | 0.06 | 0.715 (0.476, 1.073) | 0.11 | 43 | 0.352 (0.077, 1.613) | 0.18 | 0.177 (0.023, 1.342) | 0.09 |
PFNA | ||||||||||
 Low | 266 | 1.00 | 0.92 | 1.00 | 0.71 | 19 | 1.00 | 0.06 | 1.00 | 0.06 |
 Medium | 286 | 1.016 (0.795, 1.298) | 0.978 (0.751, 1.275) | 11 | 1.373 (0.469, 4.017) | 1.373 (0.469, 4.017) | ||||
 High | 277 | 1.013 (0.791, 1.297) | 0.949 (0.723, 1.247) | 12 | 3.117 (0.975, 9.964) | 3.117 (0.975, 9.964) | ||||
 log [PFNA, ng/mL] | 829f | 0.941 (0.681, 1.301) | 0.71 | 0.837 (0.587, 1.195) | 0.33 | 42 f | 1.360 (0.293, 6.309) | 0.69 | 1.360 (0.293, 6.309) | 0.69 |
PFUnDA | ||||||||||
 Low | 290 | 1.00 | 0.14 | 1.00 | 0.08 | 22 | 1.00 | 0.20 | 1.00 | 0.04 |
 Medium | 318 | 1.096 (0.863, 1.391) | 1.100 (0.853, 1.419) | 17 | 0.847 (0.341, 2.101) | 0.476 (0.157, 1.445) | ||||
 High | 251 | 0.828 (0.646, 1.062) | 0.784 (0.600, 1.024) | 4 | 0.365 (0.090, 1.469) | 0.179 (0.033, 0.970) | ||||
 log [PFUnDA, ng/mL] | 859 | 0.838 (0.649, 1.082) | 0.18 | 0.827 (0.628, 1.091) | 0.18 | 43 | 0.769 (0.251, 2.354) | 0.65 | 0.377 (0.095, 1.494) | 0.16 |
PFHxS | ||||||||||
 Low | 334 | 1.00 | 0.01 | 1.00 | 0.05 | 29 | 1.00 | 0.92 | 1.00 | 0.18 |
 Medium | 253 | 0.700 (0.548, 0.893) | 0.762 (0.589, 0.986) | 10 | 1.102 (0.381, 3.192) | 0.659 (0.184, 2.359) | ||||
 High | 272 | 0.733 (0.573, 0.939) | 0.769 (0.592, 0.999) | 4 | 0.817 (0.170, 3.936) | 0.286 (0.043, 1.892) | ||||
 log [PFHxS, ng/mL] | 859 | 0.728 (0.539, 0.985) | 0.04 | 0.759 (0.511, 1.044) | 0.09 | 43 | 1.095 (0.317, 3.788) | 0.89 | 0.577 (0.143, 2.325) | 0.44 |
PFOS | ||||||||||
 Low | 293 | 1.00 | 0.35 | 1.00 | 0.26 | 25 | 1.00 | 0.23 | 1.00 | 0.57 |
 Medium | 284 | 0.903 (0.708, 1.150) | 0.843 (0.653, 1.088) | 13 | 1.620 (0.559, 4.691) | 1.796 (0.493, 6.546) | ||||
 High | 282 | 0.888 (0.694, 1.135) | 0.860 (0.661, 1.118) | 5 | 2.345 (0.439, 12.536) | 1.208 (0.163, 8.944) | ||||
 log [PFOS, ng/mL] | 859 | 0.951 (0.703, 1.288) | 0.75 | 0.885 (0.641, 1.223) | 0.46 | 43 | 2.006 (0.472, 8.524) | 0.35 | 0.900 (0.166, 4.876) | 0.90 |
MeFOSAA | ||||||||||
 Low | 329 | 1.00 | 0.09 | 1.00 | 0.31 | 20 | 1.00 | 0.99 | 1.00 | 0.73 |
 Medium | 265 | 0.829 (0.652, 1.055) | 0.865 (0.670, 1.116) | 13 | 0.539 (0.181, 1.609) | 0.332 (0.092, 1.200) | ||||
 High | 265 | 0.816 (0.642, 1.037) | 0.877 (0.677, 1.135) | 10 | 1.033 (0.322, 3.313) | 0.876 (0.223, 3.445) | ||||
 log [MeFOSAA, ng/mL] | 859 | 0.854 (0.695, 1.049) | 0.13 | 0.929 (0.743, 1.161) | 0.52 | 43 | 1.567 (0.601, 4.089) | 0.36 | 1.414 (0.465, 4.293) | 0.54 |