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Table 5 Logistic regression models for the selected exposures and hypertensive disorders of pregnancy/preeclampsia

From: Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the risk of hypertensive disorders of pregnancy

PFAS

Hypertensive disorders of pregnancy

Preeclampsia

aAOR (95% CI)

 

PFBS

 bStandardized

1.64 (1.09–2.47)

1.81 (1.03–3.17)

 T1 (≤0.0398)

1

1

 T2 (0.0399–0.0554)

0.89 (0.39–2.44)

2.09 (0.51–8.53)

 T3 (0.0556–0.4612)

2.26 (1.02–5.02)

3.51 (0.94–13.2)

P value for linear trend

0.03

0.05

PFHxS

 bStandardized

0.79 (0.55–1.13)

0.82 (0.49–1.37)

 T1 (≤0.11402)

1

1

 T2 (0.1403–0.1831)

0.94 (0.43–2.03)

1.14 (0.36–3.58)

 T3 (0.1834–0.8465)

0.61 (0.26–1.41)

0.92 (0.27–3.11)

P value for linear trend

0.79

0.88

PFDoA

 bStandardized

0.76 (0.55–1.04)

 

 T1 (≤0.0775)

1

NA

 T2 (0.0776–0.1118)

0.89 (0.42–1.88)

 

 T3 (0.112–1.1357)

0.54 (0.23–1.29)

 

P value for linear trend

0.77

NA

PFUA

 bStandardized

NA

0.82 (0.53–1.27)

 T1 (≤0.3276)

 

1

 T2 (0.3277–0.4808)

 

0.83 (0.29–2.41)

 T3 (0.4819–5.2653)

 

0.49 (0.13–1.75)

P value for linear trend

NA

0.28

  1. Variance inflation variance (VIF) for exposures ranged from 1.01 to 1.1
  2. aAdjusting for age, education, pre-pregnancy BMI, parity and mutual adjustment of PFAS including in the corresponding model
  3. Abbreviations: T1 tertile 1, T2 tertile 2, T3 tertile 3
  4. bStandardized: PFAS concentration was subtracted by mean and then divided by its standard deviation