Reference | Country, years | N | Urinary pesticides | Timing of urine collection | Birth size outcome(s) | Notes1 | Results2 | Interaction with maternal or child PON1 genotype or phenotype |
---|---|---|---|---|---|---|---|---|
Berkowitz et al. 2004 [143] | +USA, 1998-2002 | 404 | TCPy, 3-PBA | 3rd trimester | BW BL HC | primiparous only | Â | Low maternal AREase activity - HC (TCPy) |
Wolff et al. 2007 [178] | +USA, 1998-2002 | 404 | MDA ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | 3rd trimester | BW BL HC | primiparous only | - HC (∑DAP) | Low maternal AREase activity - BL (∑DMP) Maternal PON1192 QQ: - BW (∑DEP) |
Chevrier et al. 2011 [179] | France, 2002-2006 | 579 | atrazine, atrazine mercapturate, simazine, simazine mercapturate, desethylatrazine, desisopropyl atrazine, 2-chlorodiaminoatrazine, hydroxyatrazine, hydroxysimazine, hydroxydesethylatrazine, hydroxy-desisopropyl atrazine, hydroxy-2-chlorodiaminoatrazine (ammeline), alachlor, metolachlor, acetolachlor, 2,6-diethylaniline | 1st trimester | BW BL HC | Â | - HC (metolachlor) | Â |
Eskenazi et al. 2004 [180] | +USA, 1999-2000 | 488 | MDA, TCPy, PNP, DEAMPY, IMPY, CMHC, CIT ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | 13, 26 weeks** | BW BL HC |  | + BL (PNP) + HC (∑DAP) |  |
Harley et al. 2011 [181] | +USA, 1999-2000 | 467 | ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | 13, 26 weeks** | BW BL HC |  |  | Child PON1-108 CT: + BW (∑DMP, ∑DAP) Child PON1192 RR: + BW (∑DEP) High child AREase activity: + HC (∑DMP, ∑DAP) |
Rauch et al. 2012 [182] | +USA, 2003-2006 | 306 | ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | 16, 26 weeks** | BW | not adjusted for GA | - BW (∑DMP, ∑DAP) | Child PON1-108 CT: - BW (∑DAP) Child PON1192 QR: - BW (∑DAP) |
Wang et al. 2012 [183] | China 2006-2007 | 187 | DMP, DMTP, DEP, DETP, DEDTP | delivery | BW BL | Â | NS | Â |
Zhang et al. 2014 [184] | Japan 2009-2011 | 147 | 3-PBA | 1st trimester | BW BL HC | Â | + BW (3-PBA) + HC (3-PBA) | Â |
Ding et al. 2015 [185] | China 2010 | 454 | ∑pyrethroids: cis-DCCA, trans-DCCA, 3-PBA | delivery | BW BL HC |  | - BW (∑pyrethroids) |  |
Naksen et al. 2015 [186] | Thailand 2011-2012 | 52 | ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | 12 weeks | BW BL HC |  | NS | Low maternal PON1 activity: - BW (∑DAP) - HC (∑DMP, ∑DEP, ∑DAP) High maternal PON1 activity: + BW (∑DMP) |
32 weeks | NS | Low maternal PON1 activity: - HC (∑DEP, ∑DAP) | ||||||
delivery | NS | NS | ||||||
Harley et al. 2016 [187] | USA (3 pooled studies) 1999-2006 | 1169 | ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | 1-2 samples during pregnancy | BW BL HC |  | NS | Child PON1-108 TT: + BL (∑DMP) Child PON1192 RR: - BL (∑DMP) Maternal PON1192 QR: + HC (∑DEP) |
Liu et al. 2016 [188] | China 2011-2012 | 310 | ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | delivery | BW BL HC |  | - HC (∑DAP) |  |
Woods et al. 2017 [110] | USA 2003-2006 | 272 | ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | 16, 26 weeks** | BW |  | NS |  |
Huang et al. 2017 [108] | Taiwan 2010 | 105 | ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | 11 weeks | BW BL HC |  | NS |  |
26 weeks |  | - BW (DEP) - BL (DEP, ∑DEP) |  | |||||
delivery | Â | NS | Â | |||||
Dalsager et al. 2018 [189] | Denmark 2010-2012 | 858 | TCPy, 3-PBA, 2,4-D ∑DMP: DMP, DMDTP, DMTP ∑DEP: DEP, DEDTP, DETP ∑DAP: DMP, DMDTP, DMTP, DEP, DEDTP, DETP | 28 weeks | BW HC |  | NS |  |
Parvez et al. 2018 [190] | USA 2015-2016 | 71 | Glyphosate | 11-39 weeks | BW HC | Â | NS | Â |
Zhang et al. 2018 [191] | China 2009-2010 | 1100 | Carbofuran | delivery | BW BL HC | Â | NS | Â |