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Table 6 Multivariate regression analyses between arsenic exposure and early genotoxic effects in newborns

From: Correction to: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study

Ā 

Coefficient Ī² [adjusted p-value] (95%CI)

DNA base damage

DNA strand breaks

Micronucleus frequency

8-OHdG

8-Nitroguanine

Tail Length

Olive Mom.

%DNA in tail

Mononucleated

Binucleated

Toenail As

0.234 [0.010]

0.210 [0.031]

0.360 [0.000]

0.192 [0.000]

0.273 [0.000]

0.325 [0.000]

āˆ’0.029 [0.958]

(Ī¼g/L)

(0.089, 0.379)

(0.064, 0.356)

(0.221, 0.499)

(0.045, 0.339)

(0.124, 0.422)

(0.177, 0.472)

(āˆ’0.175, 0.118)

Urinary Total As

0.003 [0.974]

āˆ’0.063 [0.518]

0.142 [0.140]

0.232 [0.000]

0.165 [0.073]

0.100 [0.220]

0.090 [0.146]

(Ī¼g/g creatinine)

(āˆ’0.153, 0.158)

(āˆ’ā€‰0.219, 0.094)

(āˆ’ā€‰0.001, 0.285)

(0.089, 0.376)

(0.020, 0.310)

(āˆ’0.056, 0.256)

(āˆ’ā€‰0.052, 0.232)

Urinary iAs

āˆ’0.038 [0.974]

0.109 [0.423]

0.021 [0.781]

0.093 [0.112]

0.060 [0.359]

āˆ’0.034 [0.339]

0.050 [0.146]

(Ī¼g/L)

(āˆ’0.183, 0.107)

(āˆ’ā€‰0.037, 0.255)

(āˆ’ā€‰0.114, 0.156)

(āˆ’ā€‰0.042, 0.228)

(āˆ’0.077, 0.197)

(āˆ’ā€‰0.213, 0.144)

(āˆ’ā€‰0.119, 0.219)

Urinary MMA

0.012 [0.974]

0.076 [0.518]

0.054 [0.538]

0.087 [0.027]

0.073 [0.268]

0.163 [0.091]

0.153 [0.114]

(Ī¼g/L)

(āˆ’0.137, 0.161)

(āˆ’0.074, 0.226)

(āˆ’ā€‰0.085, 0.192)

(āˆ’ā€‰0.052, 0.226)

(āˆ’0.068, 0.214)

(0.016, 0.311)

(0.011, 0.295)

Urinary DMA

āˆ’0.006 [0.974]

āˆ’0.060 [0.518]

0.085 [0.538]

0.003 [0.056]

0.029 [0.375]

āˆ’0.012 [0.255]

āˆ’ā€‰0.011 [0.227]

(Ī¼g/L)

(āˆ’0.155, 0.143)

(āˆ’ā€‰0.209, āˆ’ā€‰0.090)

(āˆ’0.053, 0.223)

(āˆ’ā€‰0.148, 0.153)

(āˆ’ā€‰0.123, 0.181)

(āˆ’ā€‰0.208, 0.183)

(āˆ’ā€‰0.199, 0.177)

Cord blood

āˆ’0.105 [0.503]

āˆ’ā€‰0.026 [0.732]

0.270 [0.001]

0.316 [0.000]

0.264 [0.001]

0.094 [0.255]

0.519 [0.000]

(Ī¼g/L)

(āˆ’0.254, 0.044)

(āˆ’0.177, 0.125)

(0.131, 0.409)

(0.178, 0.454)

(0.125, 0.404)

(āˆ’ā€‰0.054, 0.242)

(0.380, 0.657)

  1. Model was adjusted for the covariates including age, BMI, education, occupation, gestational age of sample collection during pregnancy (urine and nail samples) and baby delivery (cord blood sample)
  2. The raw p-values were subjected to multiple testing corrections using FDR-adjusted p-value and the statistically significant are highlighted in bold
  3. Ī² represents standardized coefficient; 95% CI represents 95% confidence interval (CI)
  4. Olive tail moment is the product of the tail length and the fraction of total DNA in the tail
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Environmental Health

ISSN: 1476-069X