Table 7 Generalized estimating equation analysis of ≥ 2 repeated measurements of cardiovascular disease markers over 4 years

Variables^a

N

Mean ± SD

N

Mean ± SD

N

Mean ± SD

RL1*Time

RL2*Time

RL1*Time

paraoxonase (unit/ml) 1st

34

1121.64 ± 401.63

51

1196.94 ± 488.25

44

1205.68 ± 390.9

-10.619 (14.943)

-18.242 (12.892)

-9.259 (6.455)

paraoxonase (unit/ml) 2nd

74

900.4 ± 337.11

82

920.9 ± 358.07

67

936.96 ± 312.4

paraoxonase (unit/ml) 3rd

73

869.72 ± 338.36

74

951.92 ± 298.78

72

915.69 ± 292.91

paraoxonase (unit/ml) 4th

79

830.34 ± 325.89

68

920.14 ± 352.64

65

851.78 ± 314.39

paraoxonase (unit/ml) 5th

64

779.12 ± 300.61

52

872.7 ± 341.33

57

847.03 ± 286.93

SDNN (ms) 1st

34

39.09 ± 12.02

52

45.91 ± 17.25

45

43.57 ± 15.45

-1.541 (0.873)

-1.614 (0.887)

-0.817 (0.444)

SDNN (ms) 2nd

75

39.59 ± 16.06

81

43.57 ± 18.71

67

44.33 ± 17.26

SDNN (ms) 3rd

73

43.64 ± 18.82

74

43.92 ± 17.18

71

44.2 ± 18.42

SDNN (ms) 4th

80

39.25 ± 16.21

66

40.1 ± 14.12

65

39.35 ± 17.8

SDNN (ms) 5th

62

39.6 ± 16.47

51

42.11 ± 16.31

57

37.65 ± 13.69

RMSSD (ms) 1st

34

25.07 ± 11.06

52

32.92 ± 14.96

46

31.02 ± 15.77

-1.234 (0.716)

-1.203(0.763)

-0.596 (0.383)

RMSSD (ms) 2nd

73

27.4 ± 13.68

81

31.46 ± 18.8

66

30.56 ± 16.39

RMSSD (ms) 3rd

72

29.34 ± 14.52

73

28.5 ± 15.21

70

28.84 ± 14.93

RMSSD (ms) 4th

79

24.13 ± 11.42

67

27.09 ± 13.8

64

24.62 ± 12.9

RMSSD (ms) 5th

65

23.6 ± 10.29

51

25.54 ± 12.35

57

24.88 ± 12.31

VLF (ms2) 1st

34

595.94 ± 546.57

51

652.99 ± 516.35

44

568.88 ± 381.44

-35.240 (35.351)

-24.379 (33.075)

-12.450 (16.564)

VLF (ms2) 2nd

74

572.78 ± 560.28

79

655.26 ± 636.07

66

642.27 ± 536.73

VLF (ms2) 3rd

71

573.79 ± 543.63

70

546.25 ± 448.1

65

561.91 ± 539.93

VLF (ms2) 4th

78

510.31 ± 421.48

67

646.18 ± 601.7

61

520.77 ± 495.83

VLF (ms2) 5th

59

642.16 ± 641.35

49

576.27 ± 522

55

532.74 ± 510.33

LF (ms2) 1st

35

611.56 ± 480.14

52

694.45 ± 613.32

44

751.32 ± 739

-14.202 (30.830)

-53.531 (32.371)

-25.967 (16.115)

LF (ms2) 2nd

73

447.93 ± 386.22

79

575.7 ± 544.75

65

598.24 ± 536.82

LF (ms2) 3rd

71

486.59 ± 495.96

73

554.67 ± 533.98

69

611.94 ± 594.38

LF (ms2) 4th

78

424.3 ± 419.4

66

522.92 ± 448.81

62

508.42 ± 484.99

LF (ms2) 5th

62

560.55 ± 540.79

50

657.62 ± 554.21

57

465.33 ± 445.06

HF (ms2) 1st

34

235.81 ± 236.02

50

236.19 ± 171

45

296.39 ± 254.19

5.993 (10.816)

1.368 (12.301)

0.841 (6.119)

HF (ms2) 2nd

73

225.51 ± 189.97

77

259.41 ± 226.35

64

234.28 ± 141.02

HF (ms2) 3rd

70

230.99 ± 202.36

70

261.96 ± 242.84

68

281.85 ± 236.15

HF (ms2) 4th

76

185.35 ± 171.39

65

263.85 ± 246.1

63

253.78 ± 271.83

HF (ms2) 5th

62

193.68 ± 165.35

50

254.4 ± 219.26

56

192.98 ± 167.61

LF/HF ratio 1st

35

3.34 ± 1.96

51

3.04 ± 2.57

45

3.93 ± 3.62

0.026 (0.149)

-202 (0.162)

-0.105 (0.081)

LF/HF ratio 2nd

73

2.55 ± 2.09

78

2.69 ± 2.46

66

2.96 ± 2.53

LF/HF ratio 3rd

71

2.55 ± 2.51

73

2.68 ± 2.56

72

3.05 ± 2.83

LF/HF ratio 4th

77

2.76 ± 2.53

63

2.35 ± 1.79

62

2.75 ± 2.51

LF/HF ratio 5th

61

3.09 ± 2.47

51

3.59 ± 3.21

56

3.23 ± 2.74