Use of skincare products and risk of cancer of the breast and endometrium: a prospective cohort study

Table 2 Associations between skincare product use and incidence of pre−/postmenopausal breast and endometrial cancer

User groups of skincare products per cancer type	n	Cancer cases	Age-adjusted HR (95% CI)	Multivariable HR (95% CI)	p_trend
Premenopausal breast cancer^a
Non−/Light users	7988	238	1.00	1.00	0.56
Moderate users	4642	146	1.05 (0.86,1.30)	1.05 (0.85,1.29)
Frequent/heavy users	7215	237	1.11 (0.93,1.33)	1.10 (0.92,1.32)
Postmenopausal breast cancer^b
Non-users	1549	49	1.12 (0.84,1.49)	1.14 (0.85,1.52)	0.27
Light users	32,379	922	1.00	1.00
Moderate users	22,762	656	1.00 (0.90, 1.10)	0.99 (0.89,1.09)
Frequent users	29,874	854	0.99 (0.90, 1.09)	0.97 (0.88,1.07)
Heavy users	1752	45	0.89 (0.66, 1.20)	0.87 (0.65,1.18)
Endometrial cancer^c
Non−/Light users	25,774	213	1.00	1.00	0.63
Moderate users	16,556	98	0.70 (0.55,0.88)	0.77 (0.61,0.98)
Frequent/heavy users	23,156	163	0.83 (0.68,1.02)	0.97 (0.79,1.20)

HR hazard ratio, CI confidence interval
^aMultivariable adjusted for maternal breast cancer history and alcohol intake
^bMultivariable adjusted for body mass index, use of menopause hormone therapy, age at first birth and parity combined, maternal breast cancer history, physical activity and alcohol intake
^cMultivariable adjusted for body mass index, use of oral contraceptives, use of intrauterine device, smoking and education

ISSN: 1476-069X