Fig. 7From: Dibutyl phthalate promotes juvenile Sertoli cell proliferation by decreasing the levels of the E3 ubiquitin ligase Pellino 2Proposed model for MBP-induced abnormal cell growth of juvenile SCs. MBP at 0.1 mM inhibits the expression of Peli2, leading to K63 ubiquitination of IRAK1, which activates the MAPK/JNK signalling pathway and promotes SC proliferation. MBP at 10 mM led to SC apoptosis through intrinsic apoptotic signalling pathwaysBack to article page