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Table 3. Adjusted odds of asthma (coded as either dichotomous outcome (A) or multinomial outcome (B)) per unit increase in exposure to natural-log transformed B[a]P and stratified according to atopy- and sex-

From: Airborne Benzo[a]Pyrene may contribute to divergent Pheno-Endotypes in children

 

Main exposure

Main Health Outcome groups of interest

  

Non-atopic Children

 

Atopic Children

(A).

 

Control (Reference)

  

Asthmatics

 

Control (Reference)

  

Asthmatics

  

N

  

N

 

N

  

N

OR (95% CI)

OR (95% CI)

 

OR (95% CI)

OR (95% CI)

P-value

P-value

 

P-value

P-value

Male

one ln-unit B[a]P

N = 63

  

N = 20

 

N = 8

  

N = 55

1

4.7 (1.9―11.5)

 

1

2.0 (0.4―11.1)

 

P = 0.001

  

P = 0.331

Female

one ln-unit B[a]P

N = 58

  

N = 1

 

N = 6

  

N = 34

1

44.8 (4.7―428.2)

 

1

3.0 (0.7―12.7)

 

P = 0.001

  

P = 0.173

(B).

 

Lean Control (Reference)

OV/OB Control

Lean Asthmatics

OV/OB Asthmatics

 

Lean Control (reference)

OV/OB Control

Lean Asthmatics

OV/OB Asthmatics

  

N

N

N

N

 

N

N

N

N

OR (95% CI)

OR (95% CI)c

OR (95% CI)

OR (95% CI)

 

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

P-value

P-value

P-value

P-value

 

P-value

P-value

P-value

P-value

Male

one ln-unit B[a]P

N = 56

N = 7

N = 17

N = 3

 

N = 7

N = 1

N = 43

N = 12

1

0.3 (0.11.0)

9.6 (2.9―32.1)

0.3 (0.12.1)

 

1

0.4 (0.0173.1)

1.6 (0.39.7)

2.2 (0.314.9)

 

P = 0.054

P < 0.001

P = 0.247

  

P = 0.786

P = 0.594

P = 0.409

Female

one ln-unit B[a]P

N = 55

N = 3

N = 11

N = 6

 

N = 5

N = 1

N = 23

N = 11

1

0.3 (0.02.9)

27.4 (3.2―237.1)

46.1 (1.7―1271.4)

 

1

0.0 (0.00.0)

3.6 (0.623.3)

17.1 (1.8―165.6)

 

P = 0.286

P = 0.003

P = 0.024

  

P = 0.998

P = 0.173

P = 0.014

  1. The dichotomous outcome model adjusts for Creatinine adjusted Cotinine, (ln) 15-F-2t-IsoP, (ln) 8-oxodG, and lung function deficit. The models adjust for Cotinine, lung function deficit, 15-F2t-IsoP, and 8-oxodG