From: Occupational exposure to polycyclic aromatic hydrocarbons and risk of prostate cancer
Exposure | Low-grade prostate cancer n = 1,488 | High-grade prostate cancer n = 436 | |||||
---|---|---|---|---|---|---|---|
n Co | n Ca | ORa | 95%CI | n Ca | ORa | 95%CI | |
PAHs from any source | |||||||
Never exposed to any source | 1053 | 803 | 1.00 | Ref | 211 | 1.00 | Ref |
Ever exposed | 573 | 420 | 0.97 | (0.81, 1.17) | 142 | 1.08 | (0.83, 1.42) |
Duration (per 5-year increment) | 573 | 420 | 0.99 | (0.96, 1.03) | 142 | 1.01 | (0.97, 1.07) |
Cumulative exposure | |||||||
0.01—300.00 | 303 | 221 | 0.96 | (0.78, 1.19) | 73 | 1.06 | (0.78, 1.46) |
300.01—1049.66 | 125 | 91 | 0.95 | (0.70, 1.30) | 39 | 1.28 | (0.84, 1.95) |
> 1049.66 | 143 | 108 | 1.02 | (0.75, 1.39) | 30 | 0.93 | (0.58, 1.47) |
p for trend | 0.86 | 0.79 | |||||
Benzo[a]pyrene | |||||||
Ever exposed | 188 | 136 | 0.98 | (0.74, 1.30) | 46 | 1.08 | (0.71, 1.64) |
Duration (per 5-year increment) | 188 | 136 | 0.96 | (0.91, 1.02) | 46 | 1.00 | (0.93, 1.09) |
Cumulative exposure | |||||||
0.01—226.95 | 94 | 82 | 1.17 | (0.83, 1.66) | 22 | 0.97 | (0.57, 1.67) |
226.96—588.00 | 42 | 27 | 0.86 | (0.51, 1.46) | 15 | 1.57 | (0.81, 3.04) |
> 588.00 | 52 | 28 | 0.68 | (0.40, 1.17) | 9 | 0.85 | (0.38, 1.90) |
p for trend | 0.16 | 0.85 | |||||
PAHs from petroleum | |||||||
Ever exposed | 518 | 390 | 1.01 | (0.84, 1.22) | 126 | 1.03 | (0.78, 1.36) |
Duration (per 5-year increment) | 518 | 390 | 1.00 | (0.97, 1.04) | 126 | 1.02 | (0.97, 1.07) |
Cumulative exposure | |||||||
0.01—240.50 | 266 | 209 | 1.04 | (0.83, 1.30) | 69 | 1.12 | (0.81, 1.55) |
240.51—901.00 | 120 | 87 | 0.89 | (0.65, 1.22) | 28 | 0.90 | (0.56, 1.44) |
> 901.00 | 130 | 93 | 1.05 | (0.77, 1.45) | 28 | 0.93 | (0.58, 1.49) |
p for trend | 0.92 | 0.63 | |||||
PAHs from wood | |||||||
Ever exposed | 42 | 37 | 1.11 | (0.65, 1.89) | 13 | 1.37 | (0.65, 2.89) |
Duration (per 5-year increment) | 42 | 37 | 1.07 | (0.96, 1.20) | 13 | 1.01 | (0.85, 1.21) |
Cumulative exposure | |||||||
0.01—450.00 | 21 | 16 | 1.02 | (0.50, 1.08) | 8 | 1.45 | (0.59, 3.58) |
450.01—1732.50 | 10 | 4 | 0.64 | (0.19, 2.25) | 4 | 1.73 | (0.43, 6.95) |
< 1732.50 | 11 | 17 | 1.74 | (0.67, 4.56) | 1 | 0.50 | (0.05, 4.72) |
p for trend | 0.19 | 0.52 | |||||
PAHs from coal | |||||||
Ever exposed | 57 | 40 | 0.92 | (0.59, 1.44) | 17 | 1.09 | (0.58, 2.03) |
Duration (per 5-year increment) | 57 | 40 | 0.93 | (0.84, 1.03) | 17 | 0.99 | (0.87, 1.12) |
Cumulative exposure | |||||||
0.01—142.50 | 30 | 26 | 1.11 | (0.63, 1.96) | 10 | 1.27 | (0.58, 2.81) |
142.51—546.25 | 12 | 10 | 1.16 | (0.47, 2.83) | 4 | 1.13 | (0.33, 3.85) |
> 546.25 | 15 | 4 | 0.36 | (0.11, 1.12) | 3 | 0.71 | (0.19, 2.61) |
p for trend | 0.09 | 0.62 | |||||
PAHs from other sources | |||||||
Ever exposed | 88 | 69 | 0.88 | (0.60, 1.29) | 22 | 0.99 | (0.57, 1.75) |
Duration (per 5-year increment) | 88 | 69 | 1.02 | (0.94, 1.09) | 22 | 0.97 | (0.87, 1.09) |
Cumulative exposure | |||||||
0.01—200.00 | 44 | 29 | 0.83 | (0.50, 1.37) | 12 | 1.09 | (0.54, 2.19) |
200.01—725.00 | 21 | 15 | 0.75 | (0.37, 1.53) | 4 | 0.66 | (0.21, 2.07) |
> 725.00 | 23 | 25 | 1.18 | (0.59, 2.38) | 6 | 1.14 | (0.39, 3.34) |
p for trend | 0.55 | 0.97 |