Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes

Table 3 Summary of results of individual EWAS. Number of differentially methylated probes (DMPs) and differentially variable probes (DVPs) identified in individual EWAS at p < 0.05 and FDR < 0.05, where applicable

	Adjusted for sex, age, and smoking status				Adjusted for cell type proportions, age, and smoking status
	All probes		Common probes ^a		All probes		Common probes ^a
DMPs	p < 0.05		p < 0.05		p < 0.05		p < 0.05
Chile, PBMCs	24,853		13,558		46,946		23,116
Chile, buccal cells	21,745		11,896		42,563		21,336
Bangladesh, 450 K	51,839		47,876		19,913		18,301
Bangladesh, 850 K	10,422		5919		14,935		7954
DVPs	p < 0.05	*FDR* < 0.05	p < 0.05	*FDR* < 0.05	p < 0.05	*FDR* < 0.05	p < 0.05	*FDR* < 0.05
Chile, PBMCs	34,906	4	19,094	3	43,813	5	23,487	3
Chile buccal, cells	36,131	5	20,659	2	35,928	7	20,735	4
Bangladesh, 450 K	22,741	5	20,925	4	18,318	3	16,904	2
Bangladesh, 850 K	33,921	47	17,646	17	53,875	51	26,155	24

DMP differentially methylated position, DVP differentially variable position. ^a Limiting probes to 377,351 included in all four EWAS

ISSN: 1476-069X