Table 3 Stratified analyses for the association between Bisphenols and sex hormones among different BMI groups in NHANES 2011-2016a
Bisphenols | Total Testosterone(ng/dL) β(95%CI) | Estrodiol pg/mL β(95%CI) | sex hormone-binding globulin (SHBG) (nmol/L) β(95%CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|
BMI | BPA | BPS | BPFb | BPA | BPS | BPFb | BPA | BPS | BPFb |
Normal (BMI<25 kg/m2) | |||||||||
 Q1 | 0 | 0 | - | 0 | 0 | - | 0 | 0 |  |
 Q2 | -15.301 (-56.008, 25.406) | -42.339 (-97.7169, 13.039) | 0 | -0.300 (-2.852, 2.252) | -0.018 (-2.800, 2.764) | 0 | 5.700 (-0.363, 11.763) | -4.155 (-10.778, 2.467) | 0 |
 Q3 | -44.446 (-90.232, 1.340) | -1.444 (-59.518, 56.629) | 19.930 (-26.249, 66.109) | -1.387 (-4.369, 1.595) | -0.406 (-3.322, 2.509) | -0.748 (-3.081, 1.584) | -1.159 (-8.042, 5.724) | -1.604 (-8.544, 5.335) | 1.097 (-4.300, 6.495) |
 Q4 | -20.640 (-72.017, 30.736) | -20.426 (-79.364, 38.512) | 2.424 (-45.380, 50.229) | -2.128 (-5.400, 1.144) | -0.429 (-3.399, 2.540) | -0.187 (-2.581, 2.207) | 9.217 (1.753, 16.681) | -6.470 (-13.603, 0.663) | -0.245 (-5.895, 5.405) |
P for trend | 0.705 | 0.980 | 0.446 | 0.208 | 0.758 | 0.330 | 0.018 | 0.125 | 0.765 |
Overweight (BMI 25–29.9 kg/m2) | |||||||||
 Q1 | 0 | 0 | - | 0 | 0 | - | 0 | 0 |  |
 Q2 | -21.057 (-52.519, 10.405) | -20.682 (-61.043, 19.680) | 0 | -1.212 (-3.364, 0.941) | -2.157 (-4.487, 0.173) | 0 | 2.254 (-2.296, 6.805) | -0.121 (-5.177, 4.934) | 0 |
 Q3 | -44.487 (-77.418, -11.555) | -3.530 (-47.245, 40.185) | -14.431 (-46.821, 17.960) 0.383 | -2.627 (-4.878, -0.376) | -1.040 (-3.561, 1.480) | 0.071 (-1.792, 1.934) | -0.136 (-4.859, 4.587) | 2.647 (-2.736, 8.031) | -2.164 (-6.091, 1.763) |
 Q4 | -18.700 (-55.833, 18.432) | -26.164 (-71.089, 18.762) | 21.759 (-10.731, 54.249) 0.190 | -0.572 (-3.146, 2.002) | -2.160 (-4.739, 0.419) | 1.937 (0.073, 3.801) | 3.933 (-1.373, 9.239) | 2.236 (-3.249, 7.720) | 0.664 (-3.305, 4.634) |
P for trend | 0.754 | 0.377 | 0.651 | 0.875 | 0.378 | 0.684 | 0.203 | 0.359 | 0.419 |
Obesity (BMI≥30 kg/m2) | |||||||||
 Q1 | 0 | 0 | - | 0 | 0 | - |  | 0 |  |
 Q2 | 11.538 (-19.286, 42.361) | 6.812 (-35.172, 48.796) | 0 | -2.901 (-5.562, -0.239) | 4.064 (1.187, 6.940) | 0 | 0 | -2.416 (-8.132, 3.299) | 0 |
 Q3 | 6.8150 (-23.995, 37.625) | 59.052 (16.075, 102.029) | -39.027 (-70.978, -7.077) | -1.056 (-3.748, 1.637) | 6.394 (3.449, 9.340) | -0.674 (-2.903, 1.554) | -4.360 (-9.545, 0.825) | 2.348 (-3.558, 8.254) | -5.074 (-9.395, -0.753) |
 Q4 | 13.431 (-19.277, 46.138) | 14.184 (-31.819, 60.188) | 19.215 (-11.780, 50.210) | -1.020 (-3.848, 1.807) | 3.289 (0.136, 6.442) | 1.068 (-1.089, 3.225) | -2.813 (-8.011, 2.386) | -1.824 (-8.211, 4.564) | -5.202 (-9.372, -1.031) |
P for trend | 0.558 | 0.897 | 0.009 | 0.787 | 0.855 | 0.413 | 0.610 | 0.655 | 0.019 |
P for interaction | 0.249 | 0.288 | 0.027 | 0.227 | 0.007 | 0.796 | 0.023 | 0.732 | 0.101 |